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BDBM371285 1-[(2,5-Dimethylpyrazol-3-yl)methyl]-7-fluoro-N-(1-methylcyclopropyl)-3-[(1-methylpyrazol-4-yl)methyl]-2,4-dioxo-quinazoline-6-sulfonamide::US10239843, Example 392

SMILES: Cc1cc(Cn2c3cc(F)c(cc3c(=O)n(Cc3cnn(C)c3)c2=O)S(=O)(=O)NC2(C)CC2)n(C)n1

InChI Key: InChIKey=JSWVSXNABFRIJT-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 371285   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
poly(ADP-ribose) glycohydrolase (PARG)


(Homo sapiens (Human))
BDBM371285
PNG
(1-[(2,5-Dimethylpyrazol-3-yl)methyl]-7-fluoro-N-(1...)
Show SMILES Cc1cc(Cn2c3cc(F)c(cc3c(=O)n(Cc3cnn(C)c3)c2=O)S(=O)(=O)NC2(C)CC2)n(C)n1
Show InChI InChI=1S/C23H26FN7O4S/c1-14-7-16(29(4)26-14)13-30-19-9-18(24)20(36(34,35)27-23(2)5-6-23)8-17(19)21(32)31(22(30)33)12-15-10-25-28(3)11-15/h7-11,27H,5-6,12-13H2,1-4H3
PDB

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US Patent
n/an/a 47n/an/an/an/an/an/a



Cancer Research Technology Limited

US Patent


Assay Description
PARG In vitro assays were conducted in a total volume of 15 ul in a standard 384 well format. 5 ul of Human Full Length PARG (Produced internally by ...


US Patent US10239843 (2019)


BindingDB Entry DOI: 10.7270/Q21R6SSM
More data for this
Ligand-Target Pair