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BDBM371330 1-[(2,5-Dimethylpyrazol-3-yl)methyl]-N-[1-(fluoromethyl)cyclopropyl]-3-[(1-methylpyrazol-4-yl)methyl]-2,4-dioxo-quinazoline-6-sulfonamide::US10239843, Example 437

SMILES: Cc1cc(Cn2c3ccc(cc3c(=O)n(Cc3cnn(C)c3)c2=O)S(=O)(=O)NC2(CF)CC2)n(C)n1

InChI Key: InChIKey=JVLFHZNOVBNDFR-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 371330   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
poly(ADP-ribose) glycohydrolase (PARG)


(Homo sapiens (Human))
BDBM371330
PNG
(1-[(2,5-Dimethylpyrazol-3-yl)methyl]-N-[1-(fluorom...)
Show SMILES Cc1cc(Cn2c3ccc(cc3c(=O)n(Cc3cnn(C)c3)c2=O)S(=O)(=O)NC2(CF)CC2)n(C)n1
Show InChI InChI=1S/C23H26FN7O4S/c1-15-8-17(29(3)26-15)13-30-20-5-4-18(36(34,35)27-23(14-24)6-7-23)9-19(20)21(32)31(22(30)33)12-16-10-25-28(2)11-16/h4-5,8-11,27H,6-7,12-14H2,1-3H3
PDB

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PC cid
PC sid
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US Patent
n/an/a 23n/an/an/an/an/an/a



Cancer Research Technology Limited

US Patent


Assay Description
PARG In vitro assays were conducted in a total volume of 15 ul in a standard 384 well format. 5 ul of Human Full Length PARG (Produced internally by ...


US Patent US10239843 (2019)


BindingDB Entry DOI: 10.7270/Q21R6SSM
More data for this
Ligand-Target Pair