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BDBM371335 N-[1-(Fluoromethyl)cyclopropyl]-3-[(1-methylpyrazol-4-yl)methyl]-2,4-dioxo-1-(tetrahydropyran-4-ylmethyl)quinazoline-6-sulfonamide::US10239843, Example 442

SMILES: Cn1cc(Cn2c(=O)n(CC3CCOCC3)c3ccc(cc3c2=O)S(=O)(=O)NC2(CF)CC2)cn1

InChI Key: InChIKey=LNZJVCRCBBPZAH-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 371335   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
poly(ADP-ribose) glycohydrolase (PARG)


(Homo sapiens (Human))
BDBM371335
PNG
(N-[1-(Fluoromethyl)cyclopropyl]-3-[(1-methylpyrazo...)
Show SMILES Cn1cc(Cn2c(=O)n(CC3CCOCC3)c3ccc(cc3c2=O)S(=O)(=O)NC2(CF)CC2)cn1
Show InChI InChI=1S/C23H28FN5O5S/c1-27-12-17(11-25-27)14-29-21(30)19-10-18(35(32,33)26-23(15-24)6-7-23)2-3-20(19)28(22(29)31)13-16-4-8-34-9-5-16/h2-3,10-12,16,26H,4-9,13-15H2,1H3
PDB

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US Patent
n/an/a 43n/an/an/an/an/an/a



Cancer Research Technology Limited

US Patent


Assay Description
PARG In vitro assays were conducted in a total volume of 15 ul in a standard 384 well format. 5 ul of Human Full Length PARG (Produced internally by ...


US Patent US10239843 (2019)


BindingDB Entry DOI: 10.7270/Q21R6SSM
More data for this
Ligand-Target Pair