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BDBM371352 N-[1-(Difluoromethyl)cyclopropyl]-1-[(4-fluorophenyl)methyl]-3-[(1-methylpyrazol-4-yl)methyl]-2,4-dioxo-quinazoline-6-sulfonamide::US10239843, Example 460

SMILES: Cn1cc(Cn2c(=O)n(Cc3ccc(F)cc3)c3ccc(cc3c2=O)S(=O)(=O)NC2(CC2)C(F)F)cn1

InChI Key: InChIKey=JXPPXPCUFYCFAC-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 371352   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
poly(ADP-ribose) glycohydrolase (PARG)


(Homo sapiens (Human))
BDBM371352
PNG
(N-[1-(Difluoromethyl)cyclopropyl]-1-[(4-fluorophen...)
Show SMILES Cn1cc(Cn2c(=O)n(Cc3ccc(F)cc3)c3ccc(cc3c2=O)S(=O)(=O)NC2(CC2)C(F)F)cn1
Show InChI InChI=1S/C24H22F3N5O4S/c1-30-12-16(11-28-30)14-32-21(33)19-10-18(37(35,36)29-24(8-9-24)22(26)27)6-7-20(19)31(23(32)34)13-15-2-4-17(25)5-3-15/h2-7,10-12,22,29H,8-9,13-14H2,1H3
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US Patent
n/an/a 333n/an/an/an/an/an/a



Cancer Research Technology Limited

US Patent


Assay Description
PARG In vitro assays were conducted in a total volume of 15 ul in a standard 384 well format. 5 ul of Human Full Length PARG (Produced internally by ...


US Patent US10239843 (2019)


BindingDB Entry DOI: 10.7270/Q21R6SSM
More data for this
Ligand-Target Pair