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BDBM371363 1-[(1-Methoxycyclopentyl)methyl]-N-(1-methylcyclopropyl)-3-[(3-methylisoxazol-5-yl)methyl]-2,4-dioxo-quinazoline-6-sulfonamide::US10239843, Example 471

SMILES: COC1(Cn2c3ccc(cc3c(=O)n(Cc3cc(C)no3)c2=O)S(=O)(=O)NC2(C)CC2)CCCC1

InChI Key: InChIKey=UYSXPHCMYDFOMU-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 371363   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
poly(ADP-ribose) glycohydrolase (PARG)


(Homo sapiens (Human))
BDBM371363
PNG
(1-[(1-Methoxycyclopentyl)methyl]-N-(1-methylcyclop...)
Show SMILES COC1(Cn2c3ccc(cc3c(=O)n(Cc3cc(C)no3)c2=O)S(=O)(=O)NC2(C)CC2)CCCC1
Show InChI InChI=1S/C24H30N4O6S/c1-16-12-17(34-25-16)14-27-21(29)19-13-18(35(31,32)26-23(2)10-11-23)6-7-20(19)28(22(27)30)15-24(33-3)8-4-5-9-24/h6-7,12-13,26H,4-5,8-11,14-15H2,1-3H3
PDB

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US Patent
n/an/a 550n/an/an/an/an/an/a



Cancer Research Technology Limited

US Patent


Assay Description
PARG In vitro assays were conducted in a total volume of 15 ul in a standard 384 well format. 5 ul of Human Full Length PARG (Produced internally by ...


US Patent US10239843 (2019)


BindingDB Entry DOI: 10.7270/Q21R6SSM
More data for this
Ligand-Target Pair