BDBM371376 1-Chloro-N-(1-methylcyclopropyl)isoquinoline-7-sulfonamide::US10239843, Example 484

SMILES CC1(CC1)NS(=O)(=O)c1ccc2ccnc(Cl)c2c1

InChI Key InChIKey=HJSXARKGWKUBAJ-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 371376   

TargetPoly(ADP-ribose) glycohydrolase(Homo sapiens (Human))
Cancer Research Technology

US Patent
LigandPNGBDBM371376(1-Chloro-N-(1-methylcyclopropyl)isoquinoline-7-sul...)
Affinity DataIC50:  4.12E+3nMAssay Description:PARG In vitro assays were conducted in a total volume of 15 ul in a standard 384 well format. 5 ul of Human Full Length PARG (Produced internally by ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Cancer Research Technology

US Patent
LigandPNGBDBM371376(1-Chloro-N-(1-methylcyclopropyl)isoquinoline-7-sul...)
Affinity DataIC50: >1.50E+5nMAssay Description:PARP1 In vitro selectivity assays were conducted as a 10 ul reaction volume in a NUNC Maxisorp 384-well assay plate pre-coated in-house with Histones...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetADP-ribosylhydrolase ARH3(Homo sapiens (Human))
Cancer Research Technology

US Patent
LigandPNGBDBM371376(1-Chloro-N-(1-methylcyclopropyl)isoquinoline-7-sul...)
Affinity DataIC50: >1.50E+5nMAssay Description:ARH3 In vitro selectivity assays were conducted in a total volume of 15 ul in a standard 384 well format. 5 ul of Human Full Length ARH3 (Enzo Life S...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent