BindingDB logo
myBDB logout

BDBM371434 1-[(4-Cyanophenyl)methyl]-N-[1-(fluoromethyl)cyclopropyl]-3-[(1-methylpyrazol-4-yl)methyl]-2,4-dioxo-quinazoline-6-sulfonamide::US10239843, Example 543

SMILES: Cn1cc(Cn2c(=O)n(Cc3ccc(cc3)C#N)c3ccc(cc3c2=O)S(=O)(=O)NC2(CF)CC2)cn1

InChI Key: InChIKey=JAJZGLLHZJEQND-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 371434   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
poly(ADP-ribose) glycohydrolase (PARG)


(Homo sapiens (Human))
BDBM371434
PNG
(1-[(4-Cyanophenyl)methyl]-N-[1-(fluoromethyl)cyclo...)
Show SMILES Cn1cc(Cn2c(=O)n(Cc3ccc(cc3)C#N)c3ccc(cc3c2=O)S(=O)(=O)NC2(CF)CC2)cn1
Show InChI InChI=1S/C25H23FN6O4S/c1-30-13-19(12-28-30)15-32-23(33)21-10-20(37(35,36)29-25(16-26)8-9-25)6-7-22(21)31(24(32)34)14-18-4-2-17(11-27)3-5-18/h2-7,10,12-13,29H,8-9,14-16H2,1H3
PDB

Reactome pathway

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 58n/an/an/an/an/an/a



Cancer Research Technology Limited

US Patent


Assay Description
PARG In vitro assays were conducted in a total volume of 15 ul in a standard 384 well format. 5 ul of Human Full Length PARG (Produced internally by ...


US Patent US10239843 (2019)


BindingDB Entry DOI: 10.7270/Q21R6SSM
More data for this
Ligand-Target Pair