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BDBM371441 N-[1-(Fluoromethyl)cyclopropyl]-3-[(3-methylisoxazol-5-yl)methyl]-1-[(2-methylthiazol-4-yl)methyl]-2,4-dioxo-quinazoline-6-sulfonamide::US10239843, Example 550

SMILES: Cc1cc(Cn2c(=O)n(Cc3csc(C)n3)c3ccc(cc3c2=O)S(=O)(=O)NC2(CF)CC2)on1

InChI Key: InChIKey=SEDKEVZISKHOGC-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 371441   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
poly(ADP-ribose) glycohydrolase (PARG)


(Homo sapiens (Human))
BDBM371441
PNG
(N-[1-(Fluoromethyl)cyclopropyl]-3-[(3-methylisoxaz...)
Show SMILES Cc1cc(Cn2c(=O)n(Cc3csc(C)n3)c3ccc(cc3c2=O)S(=O)(=O)NC2(CF)CC2)on1
Show InChI InChI=1S/C22H22FN5O5S2/c1-13-7-16(33-25-13)10-28-20(29)18-8-17(35(31,32)26-22(12-23)5-6-22)3-4-19(18)27(21(28)30)9-15-11-34-14(2)24-15/h3-4,7-8,11,26H,5-6,9-10,12H2,1-2H3
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US Patent
n/an/a 191n/an/an/an/an/an/a



Cancer Research Technology Limited

US Patent


Assay Description
PARG In vitro assays were conducted in a total volume of 15 ul in a standard 384 well format. 5 ul of Human Full Length PARG (Produced internally by ...


US Patent US10239843 (2019)


BindingDB Entry DOI: 10.7270/Q21R6SSM
More data for this
Ligand-Target Pair