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BDBM371453 N-[1-(Fluoromethyl)cyclopropyl]-3-[(1-methylpyrazol-4-yl)methyl]-1-[(2-methyl-1,2,4-triazol-3-yl)methyl]-2,4-dioxo-quinazoline-6-sulfonamide::US10239843, Example 562

SMILES: Cn1cc(Cn2c(=O)n(Cc3ncnn3C)c3ccc(cc3c2=O)S(=O)(=O)NC2(CF)CC2)cn1

InChI Key: InChIKey=APNOAYSWDNEQMZ-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 371453   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
poly(ADP-ribose) glycohydrolase (PARG)


(Homo sapiens (Human))
BDBM371453
PNG
(N-[1-(Fluoromethyl)cyclopropyl]-3-[(1-methylpyrazo...)
Show SMILES Cn1cc(Cn2c(=O)n(Cc3ncnn3C)c3ccc(cc3c2=O)S(=O)(=O)NC2(CF)CC2)cn1
Show InChI InChI=1S/C21H23FN8O4S/c1-27-9-14(8-24-27)10-30-19(31)16-7-15(35(33,34)26-21(12-22)5-6-21)3-4-17(16)29(20(30)32)11-18-23-13-25-28(18)2/h3-4,7-9,13,26H,5-6,10-12H2,1-2H3
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US Patent
n/an/a 192n/an/an/an/an/an/a



Cancer Research Technology Limited

US Patent


Assay Description
PARG In vitro assays were conducted in a total volume of 15 ul in a standard 384 well format. 5 ul of Human Full Length PARG (Produced internally by ...


US Patent US10239843 (2019)


BindingDB Entry DOI: 10.7270/Q21R6SSM
More data for this
Ligand-Target Pair