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BDBM371456 N-[1-(Fluoromethyl)cyclopropyl]-1-[(1-methylimidazol-2-yl)methyl]-3-[(1-methylpyrazol-4-yl)methyl]-2,4-dioxo-quinazoline-6-sulfonamide::US10239843, Example 565

SMILES: Cn1cc(Cn2c(=O)n(Cc3nccn3C)c3ccc(cc3c2=O)S(=O)(=O)NC2(CF)CC2)cn1

InChI Key: InChIKey=KQQRMNWGPDZCLY-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 371456   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
poly(ADP-ribose) glycohydrolase (PARG)


(Homo sapiens (Human))
BDBM371456
PNG
(N-[1-(Fluoromethyl)cyclopropyl]-1-[(1-methylimidaz...)
Show SMILES Cn1cc(Cn2c(=O)n(Cc3nccn3C)c3ccc(cc3c2=O)S(=O)(=O)NC2(CF)CC2)cn1
Show InChI InChI=1S/C22H24FN7O4S/c1-27-8-7-24-19(27)13-29-18-4-3-16(35(33,34)26-22(14-23)5-6-22)9-17(18)20(31)30(21(29)32)12-15-10-25-28(2)11-15/h3-4,7-11,26H,5-6,12-14H2,1-2H3
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Article
US Patent
n/an/a 156n/an/an/an/an/an/a



Cancer Research Technology Limited

US Patent


Assay Description
PARG In vitro assays were conducted in a total volume of 15 ul in a standard 384 well format. 5 ul of Human Full Length PARG (Produced internally by ...


US Patent US10239843 (2019)


Article DOI: null
BindingDB Entry DOI: 10.7270/Q21R6SSM
More data for this
Ligand-Target Pair