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BDBM373550 1-[6-(2,6-Dimethyl-phenoxy)-4-dipropylamino-7-fluoro-quinazolin-2-yl]-1H-pyrazole-4-carboxylic acid;::US10246442, Example 12

SMILES: CCCN(CCC)c1nc(nc2cc(F)c(Oc3c(C)cccc3C)cc12)-n1cc(cn1)C(O)=O

InChI Key: InChIKey=LAWDPNQEEFVWPA-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 373550   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
HIF-1alpha-PHD2


(Homo sapiens (Human))
BDBM373550
PNG
(1-[6-(2,6-Dimethyl-phenoxy)-4-dipropylamino-7-fluo...)
Show SMILES CCCN(CCC)c1nc(nc2cc(F)c(Oc3c(C)cccc3C)cc12)-n1cc(cn1)C(O)=O
Show InChI InChI=1S/C26H28FN5O3/c1-5-10-31(11-6-2)24-19-12-22(35-23-16(3)8-7-9-17(23)4)20(27)13-21(19)29-26(30-24)32-15-18(14-28-32)25(33)34/h7-9,12-15H,5-6,10-11H2,1-4H3,(H,33,34)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 39.8n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
The PHD enzymatic assay was performed in 0.5 ml of reaction mixture containing the following: purified PHD2181-417 polypeptide (3 μg), synthetic...


US Patent US10246442 (2019)


BindingDB Entry DOI: 10.7270/Q2S46V9S
More data for this
Ligand-Target Pair