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BDBM375791 US9914731, Ex. No. 15

SMILES: CCNc1ccn(-c2ccc(F)cc2)c(=O)c1C(=O)Nc1ccc(Oc2cccn3nccc23)c(F)c1

InChI Key: InChIKey=AKMYEDSJQYNNTO-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 375791   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM375791
PNG
(US9914731, Ex. No. 15)
Show SMILES CCNc1ccn(-c2ccc(F)cc2)c(=O)c1C(=O)Nc1ccc(Oc2cccn3nccc23)c(F)c1
Show InChI InChI=1S/C27H21F2N5O3/c1-2-30-21-12-15-33(19-8-5-17(28)6-9-19)27(36)25(21)26(35)32-18-7-10-23(20(29)16-18)37-24-4-3-14-34-22(24)11-13-31-34/h3-16,30H,2H2,1H3,(H,32,35)
PDB
MMDB

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UniProtKB/SwissProt
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DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 55n/an/an/an/an/an/a



IGNYTA, INC.

US Patent


Assay Description
The cMET kinase assay was performed in 384-well Fluotrac™ 200 HiBase microplates using the HTRF KinEASE™ assay described above for AXL except that th...


US Patent US9914731 (2018)


BindingDB Entry DOI: 10.7270/Q2571F9C
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM375791
PNG
(US9914731, Ex. No. 15)
Show SMILES CCNc1ccn(-c2ccc(F)cc2)c(=O)c1C(=O)Nc1ccc(Oc2cccn3nccc23)c(F)c1
Show InChI InChI=1S/C27H21F2N5O3/c1-2-30-21-12-15-33(19-8-5-17(28)6-9-19)27(36)25(21)26(35)32-18-7-10-23(20(29)16-18)37-24-4-3-14-34-22(24)11-13-31-34/h3-16,30H,2H2,1H3,(H,32,35)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 550n/an/an/an/an/an/a



IGNYTA, INC.

US Patent


Assay Description
The ability of compounds to inhibit the kinase activity of recombinant human baculovirus-expressed AXL was measured by homogeneous TRF (HTRF) using C...


US Patent US9914731 (2018)


BindingDB Entry DOI: 10.7270/Q2571F9C
More data for this
Ligand-Target Pair