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BDBM375937 US9914731, Ex. No. 157

SMILES: Cc1ccc(C(=O)Nc2ccc(Oc3cc(Br)cn4nccc34)c(F)c2)c(=O)n1-c1ccc(F)cc1

InChI Key: InChIKey=RBMOHRFREXQJHO-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 375937   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM375937
PNG
(US9914731, Ex. No. 157)
Show SMILES Cc1ccc(C(=O)Nc2ccc(Oc3cc(Br)cn4nccc34)c(F)c2)c(=O)n1-c1ccc(F)cc1
Show InChI InChI=1S/C26H17BrF2N4O3/c1-15-2-8-20(26(35)33(15)19-6-3-17(28)4-7-19)25(34)31-18-5-9-23(21(29)13-18)36-24-12-16(27)14-32-22(24)10-11-30-32/h2-14H,1H3,(H,31,34)
PDB
MMDB

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KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 55n/an/an/an/an/an/a



IGNYTA, INC.

US Patent


Assay Description
The cMET kinase assay was performed in 384-well Fluotrac™ 200 HiBase microplates using the HTRF KinEASE™ assay described above for AXL except that th...


US Patent US9914731 (2018)


BindingDB Entry DOI: 10.7270/Q2571F9C
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM375937
PNG
(US9914731, Ex. No. 157)
Show SMILES Cc1ccc(C(=O)Nc2ccc(Oc3cc(Br)cn4nccc34)c(F)c2)c(=O)n1-c1ccc(F)cc1
Show InChI InChI=1S/C26H17BrF2N4O3/c1-15-2-8-20(26(35)33(15)19-6-3-17(28)4-7-19)25(34)31-18-5-9-23(21(29)13-18)36-24-12-16(27)14-32-22(24)10-11-30-32/h2-14H,1H3,(H,31,34)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 550n/an/an/an/an/an/a



IGNYTA, INC.

US Patent


Assay Description
The ability of compounds to inhibit the kinase activity of recombinant human baculovirus-expressed AXL was measured by homogeneous TRF (HTRF) using C...


US Patent US9914731 (2018)


BindingDB Entry DOI: 10.7270/Q2571F9C
More data for this
Ligand-Target Pair