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BDBM376030 N-[1-(4-fluorophenyl)-3- pyridin-4-yl-1H-pyrazol-5-yl]- 3-(1,2,4-thiadiazol-5-yl)-4- (trifluoromethyl)benzamide::US9914736, Compound 26

SMILES: Fc1ccc(cc1)-n1nc(cc1NC(=O)c1ccc(c(c1)-c1ncns1)C(F)(F)F)-c1ccncc1

InChI Key: InChIKey=IVNRTTKEKZMYJX-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 376030   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM376030
PNG
(N-[1-(4-fluorophenyl)-3- pyridin-4-yl-1H-pyrazol-5...)
Show SMILES Fc1ccc(cc1)-n1nc(cc1NC(=O)c1ccc(c(c1)-c1ncns1)C(F)(F)F)-c1ccncc1
Show InChI InChI=1S/C24H14F4N6OS/c25-16-2-4-17(5-3-16)34-21(12-20(33-34)14-7-9-29-10-8-14)32-22(35)15-1-6-19(24(26,27)28)18(11-15)23-30-13-31-36-23/h1-13H,(H,32,35)
PDB
MMDB

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US Patent
n/an/a 350n/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
In this assay, U2OS cells express the human TrkA receptor as a fusion with the weakly complementing fragment of B-galactosidase, which DiscoverX cal...


US Patent US9914736 (2018)


BindingDB Entry DOI: 10.7270/Q2WQ0629
More data for this
Ligand-Target Pair