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BDBM378933 5-methoxy-2- {1-[3-(5- methyl-1,2,4- oxadiazol-3- yl)benzyl]-1H- indazol-3-yl}- N-(pyridin-4- yl)pyrimidin-4- amine::US10266548, Example 2-2-3

SMILES: COc1cnc(nc1Nc1ccncc1)-c1nn(Cc2cccc(c2)-c2noc(C)n2)c2ccccc12

InChI Key: InChIKey=KUVPSLOVIRBFMV-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 378933   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Mitotic checkpoint serine/threonine-protein kinase BUB1


(Homo sapiens (Human))
BDBM378933
PNG
(5-methoxy-2- {1-[3-(5- methyl-1,2,4- oxadiazol-3- ...)
Show SMILES COc1cnc(nc1Nc1ccncc1)-c1nn(Cc2cccc(c2)-c2noc(C)n2)c2ccccc12
Show InChI InChI=1S/C27H22N8O2/c1-17-30-25(34-37-17)19-7-5-6-18(14-19)16-35-22-9-4-3-8-21(22)24(33-35)27-29-15-23(36-2)26(32-27)31-20-10-12-28-13-11-20/h3-15H,16H2,1-2H3,(H,28,29,31,32)
PDB
MMDB

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US Patent
n/an/a 25n/an/an/an/an/an/a



Bayer Intellectual Property GmbH

US Patent


Assay Description
Bub1-inhibitory activities of compounds described in the present invention were quantified using a time-resolved fluorescence energy transfer (TR-FRE...


US Patent US10266548 (2019)


BindingDB Entry DOI: 10.7270/Q2RV0R1M
More data for this
Ligand-Target Pair