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BDBM379102 Preparation of N-(difluoromethyl)-2-[1-(4-ethoxy-2,6-difluorobenzyl)-1H-indazol-3-yl]-N-(pyridin-4-yl)pyrimidin-4-amine::US10266548, Example 35-1

SMILES: CCOc1cc(F)c(Cn2nc(-c3nccc(n3)N(C(F)F)c3ccncc3)c3ccccc23)c(F)c1

InChI Key: InChIKey=OTQAYWVPAQNBOV-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 379102   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Mitotic checkpoint serine/threonine-protein kinase BUB1


(Homo sapiens (Human))
BDBM379102
PNG
(Preparation of N-(difluoromethyl)-2-[1-(4-ethoxy-2...)
Show SMILES CCOc1cc(F)c(Cn2nc(-c3nccc(n3)N(C(F)F)c3ccncc3)c3ccccc23)c(F)c1
Show InChI InChI=1S/C26H20F4N6O/c1-2-37-17-13-20(27)19(21(28)14-17)15-35-22-6-4-3-5-18(22)24(34-35)25-32-12-9-23(33-25)36(26(29)30)16-7-10-31-11-8-16/h3-14,26H,2,15H2,1H3
PDB
MMDB

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UniProtKB/SwissProt

antibodypedia
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PC cid
PC sid
UniChem
US Patent
n/an/a 1.30E+3n/an/an/an/an/an/a



Bayer Intellectual Property GmbH

US Patent


Assay Description
Bub1-inhibitory activities of compounds described in the present invention were quantified using a time-resolved fluorescence energy transfer (TR-FRE...


US Patent US10266548 (2019)


BindingDB Entry DOI: 10.7270/Q2RV0R1M
More data for this
Ligand-Target Pair