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BDBM379151 N2-(2-Methoxy-4-morpholinophenyl)-N4-(3-(methylsulfonyl) benzyl)-5-(trifluoromethyl)pyrimidine-2,4-diamine::US10266549, Example 52::US10774092, Example 52

SMILES: COc1cc(ccc1Nc1ncc(c(NCc2cccc(c2)S(C)(=O)=O)n1)C(F)(F)F)N1CCOCC1

InChI Key: InChIKey=UTKBUPMRLOCGPJ-UHFFFAOYSA-N

Data: 2 IC50

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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 379151   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Serine/threonine-protein kinase ULK1


(Homo sapiens (Human))
BDBM379151
PNG
(N2-(2-Methoxy-4-morpholinophenyl)-N4-(3-(methylsul...)
Show SMILES COc1cc(ccc1Nc1ncc(c(NCc2cccc(c2)S(C)(=O)=O)n1)C(F)(F)F)N1CCOCC1
Show InChI InChI=1S/C24H26F3N5O4S/c1-35-21-13-17(32-8-10-36-11-9-32)6-7-20(21)30-23-29-15-19(24(25,26)27)22(31-23)28-14-16-4-3-5-18(12-16)37(2,33)34/h3-7,12-13,15H,8-11,14H2,1-2H3,(H2,28,29,30,31)
PDB

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UniProtKB/SwissProt

antibodypedia
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PC cid
PC sid
UniChem
US Patent
n/an/a>2.00E+3n/an/an/an/an/an/a



SALK INSTITUTE FOR BIOLOGICAL STUDIES; SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE; YALE UNIVERSITY

US Patent


Assay Description
ULK1 inhibition assay is a screening assay to identify compounds that inhibit kinase activity of ULK1 using the ULKtide peptide. In some embodiments,...


US Patent US10774092 (2020)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase ULK1


(Homo sapiens (Human))
BDBM379151
PNG
(N2-(2-Methoxy-4-morpholinophenyl)-N4-(3-(methylsul...)
Show SMILES COc1cc(ccc1Nc1ncc(c(NCc2cccc(c2)S(C)(=O)=O)n1)C(F)(F)F)N1CCOCC1
Show InChI InChI=1S/C24H26F3N5O4S/c1-35-21-13-17(32-8-10-36-11-9-32)6-7-20(21)30-23-29-15-19(24(25,26)27)22(31-23)28-14-16-4-3-5-18(12-16)37(2,33)34/h3-7,12-13,15H,8-11,14H2,1-2H3,(H2,28,29,30,31)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a>2.00E+3n/an/an/an/an/an/a



Salk Institute

US Patent


Assay Description
Gamma-32P assays to measure ULK1 kinase activity were performed as previously described. Briefly, Flag ULK1 was transfected into HEK293T cells and 20...


US Patent US10266549 (2019)


BindingDB Entry DOI: 10.7270/Q2N30084
More data for this
Ligand-Target Pair