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BDBM379167 N-Methyl-2-(5-phenyl-2-(3,4,5-trimethoxyphenylamino) pyrimidin-4-ylamino)benzamide::US10266549, Example 73

SMILES: CNC(=O)c1ccccc1Nc1nc(Nc2cc(OC)c(OC)c(OC)c2)ncc1-c1ccccc1

InChI Key: InChIKey=ZDHQQZXYBJCSQV-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 379167   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Serine/threonine-protein kinase ULK1


(Homo sapiens (Human))
BDBM379167
PNG
(N-Methyl-2-(5-phenyl-2-(3,4,5-trimethoxyphenylamin...)
Show SMILES CNC(=O)c1ccccc1Nc1nc(Nc2cc(OC)c(OC)c(OC)c2)ncc1-c1ccccc1
Show InChI InChI=1S/C27H27N5O4/c1-28-26(33)19-12-8-9-13-21(19)31-25-20(17-10-6-5-7-11-17)16-29-27(32-25)30-18-14-22(34-2)24(36-4)23(15-18)35-3/h5-16H,1-4H3,(H,28,33)(H2,29,30,31,32)
PDB

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PC cid
PC sid
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US Patent
n/an/a<200n/an/an/an/an/an/a



Salk Institute

US Patent


Assay Description
Gamma-32P assays to measure ULK1 kinase activity were performed as previously described. Briefly, Flag ULK1 was transfected into HEK293T cells and 20...


US Patent US10266549 (2019)


BindingDB Entry DOI: 10.7270/Q2N30084
More data for this
Ligand-Target Pair