BDBM391742 N-(3-((2-((2-methoxy-4-(1-(methylsulfonyl)piperidin-4-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)amino)phenyl)acrylamide ::US10300058, Compound 27

SMILES COc1cc(ccc1Nc1ncc(c(Nc2cccc(NC(=O)C=C)c2)n1)C(F)(F)F)C1CCN(CC1)S(C)(=O)=O

InChI Key InChIKey=WQGDMILUIXEUMW-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 391742   

TargetEpidermal growth factor receptor(Homo sapiens (Human))
Xuanzhu Pharma

US Patent
LigandPNGBDBM391742(N-(3-((2-((2-methoxy-4-(1-(methylsulfonyl)piperidi...)
Affinity DataIC50:  8.71E+5nMAssay Description:Test compounds: a part of compounds of the invention, the chemical names and preparation methods of which can be found in their preparation examples....More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEpidermal growth factor receptor [T790M](Homo sapiens (Human))
Xuanzhu Pharma

US Patent
LigandPNGBDBM391742(N-(3-((2-((2-methoxy-4-(1-(methylsulfonyl)piperidi...)
Affinity DataIC50:  9.60E+3nMAssay Description:Test compounds: a part of compounds of the invention, the chemical names and preparation methods of which can be found in their preparation examples....More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEpidermal growth factor receptor [1-745,751-1210,T790M](Homo sapiens (Human))
Xuanzhu Pharma

US Patent
LigandPNGBDBM391742(N-(3-((2-((2-methoxy-4-(1-(methylsulfonyl)piperidi...)
Affinity DataIC50:  3.60nMAssay Description:Test compounds: a part of compounds of the invention, the chemical names and preparation methods of which can be found in their preparation examples....More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEpidermal growth factor receptor [T790M,L858R](Homo sapiens (Human))
Xuanzhu Pharma

US Patent
LigandPNGBDBM391742(N-(3-((2-((2-methoxy-4-(1-(methylsulfonyl)piperidi...)
Affinity DataIC50:  9.80nMAssay Description:Test compounds: a part of compounds of the invention, the chemical names and preparation methods of which can be found in their preparation examples....More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEpidermal growth factor receptor [1-745,751-1210](Homo sapiens (Human))
Xuanzhu Pharma

US Patent
LigandPNGBDBM391742(N-(3-((2-((2-methoxy-4-(1-(methylsulfonyl)piperidi...)
Affinity DataIC50:  36nMAssay Description:Test compounds: a part of compounds of the invention, the chemical names and preparation methods of which can be found in their preparation examples....More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEpidermal growth factor receptor [1-999,L858R](Homo sapiens (Human))
Xuanzhu Pharma

US Patent
LigandPNGBDBM391742(N-(3-((2-((2-methoxy-4-(1-(methylsulfonyl)piperidi...)
Affinity DataIC50:  88nMAssay Description:Test compounds: a part of compounds of the invention, the chemical names and preparation methods of which can be found in their preparation examples....More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent