BDBM404469 (R)-N-(1-cyanopyrrolidin- 3-yl)-3-fluoro-5-(1-methyl- 1H-pyrrolo[2,3-b]pyridin-5- yl)picolinamide::US10343992, Example 121::US10689345, Example 121::US11066365, Example 121

SMILES Cn1ccc2cc(cnc12)-c1cnc(C(=O)N[C@@H]2CCN(C2)C#N)c(F)c1

InChI Key InChIKey=SCWRPIOZZNFBHK-OAHLLOKOSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 404469   

TargetUbiquitin carboxyl-terminal hydrolase 30(Homo sapiens (Human))
Missions Therapeutics

US Patent
LigandPNGBDBM404469((R)-N-(1-cyanopyrrolidin- 3-yl)-3-fluoro-5-(1-meth...)
Affinity DataIC50: <100nMAssay Description:Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetUbiquitin carboxyl-terminal hydrolase 30(Homo sapiens (Human))
Missions Therapeutics

US Patent
LigandPNGBDBM404469((R)-N-(1-cyanopyrrolidin- 3-yl)-3-fluoro-5-(1-meth...)
Affinity DataIC50: <100nMAssay Description:USP30 biochemical fluorescence intensity IC50 assay Dilution plates were prepared at 21 times the final concentration (2100 μM for a final conce...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetUbiquitin carboxyl-terminal hydrolase 30(Homo sapiens (Human))
Missions Therapeutics

US Patent
LigandPNGBDBM404469((R)-N-(1-cyanopyrrolidin- 3-yl)-3-fluoro-5-(1-meth...)
Affinity DataIC50: <100nMAssay Description:USP30 Biochemical Fluorescence Intensity Kinetic Assay.Reactions were performed in duplicate in black 384 well plates (small volume, Greiner 784076) ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent