BDBM405588 US10351547, Compound 2-2::US10464918, Compound A::US10597377, Compound 2-2

SMILES NC1CCN(CC1)c1c(cnc2ccc(cc12)-c1cccc(C#N)c1O)-c1cc(F)cc(F)c1

InChI Key InChIKey=GHILNKWBALQPDP-UHFFFAOYSA-N

Data  6 EC50

PDB links: 1 PDB ID matches this monomer.

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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 405588   

TargetSomatostatin receptor type 2(Human)
Crinetics Pharmaceuticals

US Patent
LigandPNGBDBM405588(US10351547, Compound 2-2 | US10464918, Compound A ...)
Affinity DataEC50: <10nMAssay Description:Four days prior to the assay, 5,000 Chinese hamster ovary cells (CHO-K1, ATCC #CCL-61) stably expressing the human SSTR2 are plated in each well of a...More data for this Ligand-Target Pair
TargetSomatostatin receptor type 2(Human)
Crinetics Pharmaceuticals

US Patent
LigandPNGBDBM405588(US10351547, Compound 2-2 | US10464918, Compound A ...)
Affinity DataEC50: <10nMAssay Description:Four days prior to the assay, 5,000 Chinese hamster ovary cells (CHO-K1, ATCC #CCL-61) stably expressing the human SSTR2 are plated in each well of a...More data for this Ligand-Target Pair
TargetSomatostatin receptor type 2(Dog)
Crinetics Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM405588(US10351547, Compound 2-2 | US10464918, Compound A ...)
Affinity DataEC50:  6.60nMAssay Description:Antagonist activity at histamine H1 receptor against histamine in isolated ileum of guinea pig.More data for this Ligand-Target Pair
TargetSomatostatin receptor type 2(Human)
Crinetics Pharmaceuticals

US Patent
LigandPNGBDBM405588(US10351547, Compound 2-2 | US10464918, Compound A ...)
Affinity DataEC50:  0.25nMAssay Description:Inhibitory activity against Dihydrofolate reductase in Escherichia coliMore data for this Ligand-Target Pair
TargetSomatostatin receptor type 2(Rat)
Crinetics Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM405588(US10351547, Compound 2-2 | US10464918, Compound A ...)
Affinity DataEC50:  1.20nMAssay Description:Antagonist activity at histamine H1 receptor against histamine in isolated ileum of guinea pig.More data for this Ligand-Target Pair
TargetSomatostatin receptor type 2(Human)
Crinetics Pharmaceuticals

US Patent
LigandPNGBDBM405588(US10351547, Compound 2-2 | US10464918, Compound A ...)
Affinity DataEC50: <10nMAssay Description:Four days prior to the assay, 5,000 Chinese hamster ovary cells (CHO-K1, ATCC # CCL-61) stably expressing the human SSTR2 are plated in each well of ...More data for this Ligand-Target Pair