BDBM408072 US10336774, Example 57::US12053470, Compound 13

SMILES N[C@@H]1C[C@@H](O)CC11CCN(CC1)c1cnc(Sc2ccnc(Cl)c2Cl)c(N)n1

InChI Key InChIKey=VCACXGULTWUFOL-ZYHUDNBSSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 408072   

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
NOVARTIS AG; THE GENERAL HOSPITAL CORPORATION

US Patent
LigandPNGBDBM408072(US10336774, Example 57 | US12053470, Compound 13)
Affinity DataIC50:  3nMAssay Description:More specifically, the phosphatase reactions were performed at room temperature in 384-well black polystyrene plate, flat bottom, low flange, non-bin...More data for this Ligand-Target Pair
In DepthDetails US Patent

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
NOVARTIS AG; THE GENERAL HOSPITAL CORPORATION

US Patent
LigandPNGBDBM408072(US10336774, Example 57 | US12053470, Compound 13)
Affinity DataIC50:  3nMAssay Description:SHP2 is allosterically activated through binding of bis-tyrosyl-phorphorylated peptides to its Src Homology 2 (SH2) domains. The latter activation st...More data for this Ligand-Target Pair
In DepthDetails US Patent