BDBM418097 (2R)-2-[6-(5-chloro-2-{[(1R,3R)-3- hydroxycyclopentyl]amino}pyrimidin- 4-yl)-1-oxo-2,3-dihydro-1H-isoindol-2- yl]-N-[(1R)-1-[6- (dimethylamino)pyridin-2- yl]ethyl]propanamide::US10457669, Example 819::US11001575, Example 819

SMILES C[C@@H](NC(=O)[C@@H](C)N1Cc2ccc(cc2C1=O)-c1nc(N[C@@H]2CC[C@@H](O)C2)ncc1Cl)c1cccc(n1)N(C)C

InChI Key InChIKey=UPNBEBRFKVICQW-DEPWHIHDSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 418097   

TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
Otsuka Pharmaceutical

US Patent
LigandPNGBDBM418097((2R)-2-[6-(5-chloro-2-{[(1R,3R)-3- hydroxycyclopen...)
Affinity DataIC50:  1.90nMAssay Description:Activity of ERK2 enzyme (Life Technologies) was determined using a time-resolved fluorescence format measuring the phosphorylation of a truncated ver...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
Otsuka Pharmaceutical

US Patent
LigandPNGBDBM418097((2R)-2-[6-(5-chloro-2-{[(1R,3R)-3- hydroxycyclopen...)
Affinity DataIC50:  1.90nMAssay Description:Activity of ERK2 enzyme (Life Technologies) was determined using a time-resolved fluorescence format measuring the phosphorylation of a truncated ver...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent