BDBM418266 (2R)-2-(6-{5-chloro-2-[(1-methyl-1H- 1,2,3-triazol-5-yl)amino]pyrimidin-4- yl}-1-oxo-2,3-dihydro-1H-isoindol-2- yl)-N-[(1R)-1-[6-(4-methylpiperazin-1- yl)pyridin-2-yl]ethyl]propanamide::US10457669, Example 1048::US11001575, Example 1048

SMILES C[C@@H](NC(=O)[C@@H](C)N1Cc2ccc(cc2C1=O)-c1nc(Nc2cnnn2C)ncc1Cl)c1cccc(n1)N1CCN(C)CC1

InChI Key InChIKey=XXEZSXDKBXENNI-RTBURBONSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 418266   

TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
Otsuka Pharmaceutical

US Patent
LigandPNGBDBM418266((2R)-2-(6-{5-chloro-2-[(1-methyl-1H- 1,2,3-triazol...)
Affinity DataIC50:  1.5nMAssay Description:Activity of ERK2 enzyme (Life Technologies) was determined using a time-resolved fluorescence format measuring the phosphorylation of a truncated ver...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
Otsuka Pharmaceutical

US Patent
LigandPNGBDBM418266((2R)-2-(6-{5-chloro-2-[(1-methyl-1H- 1,2,3-triazol...)
Affinity DataIC50:  1.5nMAssay Description:Activity of ERK2 enzyme (Life Technologies) was determined using a time-resolved fluorescence format measuring the phosphorylation of a truncated ver...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent