BDBM419160 N-(4-ethylphenyl)-N- isobutyl-3-methylsulfanyl-4- (tetrahydropyran-4- ylmethoxy)benzene- sulfonamide::US10457637, Compound 25

SMILES: CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(OCC2CCOCC2)c(SC)c1

InChI Key: InChIKey=RYXBKDXGNAYCOV-UHFFFAOYSA-N

Data: 2 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 419160   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Interleukin-17A (Homo sapiens (Human))	BDBM419160 (N-(4-ethylphenyl)-N- isobutyl-3-methylsulfanyl-4- ...) Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(OCC2CCOCC2)c(SC)c1 Show InChI InChI=1S/C25H35NO4S2/c1-5-20-6-8-22(9-7-20)26(17-19(2)3)32(27,28)23-10-11-24(25(16-23)31-4)30-18-21-12-14-29-15-13-21/h6-11,16,19,21H,5,12-15,17-18H2,1-4H3	PDB Reactome pathway UniProtKB/SwissProt GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	550	n/a	n/a	n/a	n/a	n/a	n/a
GALDERMA RESEARCH & DEVELOPMENT US Patent					Assay Description This model allows measurement of the effect of inhibitors on IL-17A secretion by CD4+ cells. The cells are frozen CD4+ cells (STEMCELL, #70026), isol...				US Patent US10457637 (2019) BindingDB Entry DOI: 10.7270/Q2WS8WMG
					More data for this Ligand-Target Pair
Nuclear receptor ROR-gamma (Homo sapiens (Human))	BDBM419160 (N-(4-ethylphenyl)-N- isobutyl-3-methylsulfanyl-4- ...) Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(OCC2CCOCC2)c(SC)c1 Show InChI InChI=1S/C25H35NO4S2/c1-5-20-6-8-22(9-7-20)26(17-19(2)3)32(27,28)23-10-11-24(25(16-23)31-4)30-18-21-12-14-29-15-13-21/h6-11,16,19,21H,5,12-15,17-18H2,1-4H3	PDB Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	550	n/a	n/a	n/a	n/a	n/a	n/a
GALDERMA RESEARCH & DEVELOPMENT US Patent					Assay Description The RORγ transactivation model was developed from the line HG5LN, which is a HeLa line that stably expresses a luciferase reporter gene controll...				US Patent US10457637 (2019) BindingDB Entry DOI: 10.7270/Q2WS8WMG
					More data for this Ligand-Target Pair