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BDBM419246 N-(4-ethylphenyl)-N- isobutyl-4-(((2- methoxypyridin-4- yl)methyl)amino)-3-(S- methylsulfonimidoyl) benzenesulfonamide::US10457637, Compound 127

SMILES: CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(NCc2ccnc(OC)c2)c(c1)S(C)(=N)=O

InChI Key: InChIKey=FXTXQRXJLIGODT-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB:
Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 419246   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Interleukin-17A


(Homo sapiens (Human))
BDBM419246
PNG
(N-(4-ethylphenyl)-N- isobutyl-4-(((2- methoxypyrid...)
Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(NCc2ccnc(OC)c2)c(c1)S(C)(=N)=O
Show InChI InChI=1S/C26H34N4O4S2/c1-6-20-7-9-22(10-8-20)30(18-19(2)3)36(32,33)23-11-12-24(25(16-23)35(5,27)31)29-17-21-13-14-28-26(15-21)34-4/h7-16,19,27,29H,6,17-18H2,1-5H3
PDB

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UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 550n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
This model allows measurement of the effect of inhibitors on IL-17A secretion by CD4+ cells. The cells are frozen CD4+ cells (STEMCELL, #70026), isol...


US Patent US10457637 (2019)


BindingDB Entry DOI: 10.7270/Q2WS8WMG
More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma


(Homo sapiens (Human))
BDBM419246
PNG
(N-(4-ethylphenyl)-N- isobutyl-4-(((2- methoxypyrid...)
Show SMILES CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(NCc2ccnc(OC)c2)c(c1)S(C)(=N)=O
Show InChI InChI=1S/C26H34N4O4S2/c1-6-20-7-9-22(10-8-20)30(18-19(2)3)36(32,33)23-11-12-24(25(16-23)35(5,27)31)29-17-21-13-14-28-26(15-21)34-4/h7-16,19,27,29H,6,17-18H2,1-5H3
PDB

Reactome pathway

UniProtKB/SwissProt
UniProtKB/TrEMBL

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 550n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
The RORγ transactivation model was developed from the line HG5LN, which is a HeLa line that stably expresses a luciferase reporter gene controll...


US Patent US10457637 (2019)


BindingDB Entry DOI: 10.7270/Q2WS8WMG
More data for this
Ligand-Target Pair