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BDBM419257 N-isopropyl-N-(4-methoxy- 2-methylphenyl)-3-(S- methylsulfonimidoyl)-4- ((tetrahydro-2H-pyran-4- yl)methoxy)benzene- sulfonamide::US10457637, Compound 143

SMILES: COc1ccc(N(C(C)C)S(=O)(=O)c2ccc(OCC3CCOCC3)c(c2)S(C)(=N)=O)c(C)c1

InChI Key: InChIKey=QCNYOMWEVRZCBH-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB:
Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 419257   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Interleukin-17A


(Homo sapiens (Human))
BDBM419257
PNG
(N-isopropyl-N-(4-methoxy- 2-methylphenyl)-3-(S- me...)
Show SMILES COc1ccc(N(C(C)C)S(=O)(=O)c2ccc(OCC3CCOCC3)c(c2)S(C)(=N)=O)c(C)c1
Show InChI InChI=1S/C24H34N2O6S2/c1-17(2)26(22-8-6-20(30-4)14-18(22)3)34(28,29)21-7-9-23(24(15-21)33(5,25)27)32-16-19-10-12-31-13-11-19/h6-9,14-15,17,19,25H,10-13,16H2,1-5H3
PDB

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UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 550n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
This model allows measurement of the effect of inhibitors on IL-17A secretion by CD4+ cells. The cells are frozen CD4+ cells (STEMCELL, #70026), isol...


US Patent US10457637 (2019)


BindingDB Entry DOI: 10.7270/Q2WS8WMG
More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma


(Homo sapiens (Human))
BDBM419257
PNG
(N-isopropyl-N-(4-methoxy- 2-methylphenyl)-3-(S- me...)
Show SMILES COc1ccc(N(C(C)C)S(=O)(=O)c2ccc(OCC3CCOCC3)c(c2)S(C)(=N)=O)c(C)c1
Show InChI InChI=1S/C24H34N2O6S2/c1-17(2)26(22-8-6-20(30-4)14-18(22)3)34(28,29)21-7-9-23(24(15-21)33(5,25)27)32-16-19-10-12-31-13-11-19/h6-9,14-15,17,19,25H,10-13,16H2,1-5H3
PDB

Reactome pathway

UniProtKB/SwissProt
UniProtKB/TrEMBL

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 550n/an/an/an/an/an/a



GALDERMA RESEARCH & DEVELOPMENT

US Patent


Assay Description
The RORγ transactivation model was developed from the line HG5LN, which is a HeLa line that stably expresses a luciferase reporter gene controll...


US Patent US10457637 (2019)


BindingDB Entry DOI: 10.7270/Q2WS8WMG
More data for this
Ligand-Target Pair