BDBM420295 alpha-ketoamide inhibitor 13b::med.21724, Compound 67

SMILES CC(C)(C)OC(=O)Nc1cccn([C@@H](CC2CC2)C(=O)N[C@@H](C[C@@H]2CCNC2=O)C(=O)C(=O)NCc2ccccc2)c1=O

InChI Key InChIKey=NLVRHQFXQFSBQK-XWGVYQGASA-N

Data  8 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 420295   

TargetReplicase polyprotein 1ab [3264-3569](Severe acute respiratory syndrome coronavirus 2)
University Of Lubeck

LigandPNGBDBM420295(alpha-ketoamide inhibitor 13b | med.21724, Compoun...)
Affinity DataIC50:  670nMAssay Description:A fluorescent substrate harboring the cleavage site (indicated by the arrow, ↓) of SARS-CoV-2 Mpro(Dabcyl-KTSAVLQ↓SGFRKM-E(Edans)-NH2; GL...More data for this Ligand-Target Pair
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In DepthDetails ArticlePubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
University Of Bonn

LigandPNGBDBM420295(alpha-ketoamide inhibitor 13b | med.21724, Compoun...)
Affinity DataIC50:  670nMAssay Description:This is a review article.More data for this Ligand-Target Pair
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In DepthDetails ArticlePubMed
TargetReplicase polyprotein 1ab(Human SARS coronavirus (SARS-CoV) (Severe acute re...)
University Of Bonn

LigandPNGBDBM420295(alpha-ketoamide inhibitor 13b | med.21724, Compoun...)
Affinity DataIC50:  900nMAssay Description:This is a review article.More data for this Ligand-Target Pair
Ligand InfoPurchase
In DepthDetails ArticlePubMed
TargetOrf1a protein(MERS-CoV)
University Of Bonn

LigandPNGBDBM420295(alpha-ketoamide inhibitor 13b | med.21724, Compoun...)
Affinity DataIC50:  580nMAssay Description:This is a review article.More data for this Ligand-Target Pair
Ligand InfoPurchase
In DepthDetails ArticlePubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
University Of Bonn

LigandPNGBDBM420295(alpha-ketoamide inhibitor 13b | med.21724, Compoun...)
Affinity DataIC50:  670nMAssay Description:Inhibition of recombinant SARS-CoV-2 Main proteaseMore data for this Ligand-Target Pair
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In DepthDetails PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
University Of Bonn

LigandPNGBDBM420295(alpha-ketoamide inhibitor 13b | med.21724, Compoun...)
Affinity DataEC50:  4.50E+3nMAssay Description:This is a review article.More data for this Ligand-Target Pair
Ligand InfoPurchase
In DepthDetails ArticlePubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
University Of Bonn

LigandPNGBDBM420295(alpha-ketoamide inhibitor 13b | med.21724, Compoun...)
Affinity DataIC50:  120nMAssay Description:Inhibition of recombinant SARS-COV2 main protease using DabcylKTSAVLQISGFRKM-E(Edans)-N1-as substrate by FRET assayMore data for this Ligand-Target Pair
Ligand InfoPurchase
In DepthDetails PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
University Of Bonn

LigandPNGBDBM420295(alpha-ketoamide inhibitor 13b | med.21724, Compoun...)
Affinity DataIC50:  670nMAssay Description:Inhibition of C-terminal 6-His-tagged recombinant SARS CoV-2 3CL protease expressed in Escherichia coli BL21-Gold DE3 cells by FRET assayMore data for this Ligand-Target Pair
Ligand InfoPurchase
In DepthDetails PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
University Of Bonn

LigandPNGBDBM420295(alpha-ketoamide inhibitor 13b | med.21724, Compoun...)
Affinity DataIC50:  900nMAssay Description:Inhibition of C-terminal 6-His-tagged recombinant SARS CoV 3CL protease expressed in Escherichia coli BL21-Gold DE3 cells by FRET assayMore data for this Ligand-Target Pair
Ligand InfoPurchase
In DepthDetails PubMed
TargetReplicase polyprotein 1ab(Human SARS coronavirus (SARS-CoV) (Severe acute re...)
University Of Bonn

LigandPNGBDBM420295(alpha-ketoamide inhibitor 13b | med.21724, Compoun...)
Affinity DataEC50:  1.75E+3nMAssay Description:This is a review article.More data for this Ligand-Target Pair
Ligand InfoPurchase
In DepthDetails ArticlePubMed