BDBM420331 AMG-837

SMILES CC#CC(CC([O-])=O)c1ccc(OCc2cccc(c2)-c2ccc(cc2)C(F)(F)F)cc1

InChI Key InChIKey=ZOPNBMMVVZRSGH-UHFFFAOYSA-M

Data  1 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 420331   

TargetReplicase polyprotein 1ab(2019-nCoV)
National Institutes Of Health

LigandPNGBDBM420331(AMG-837)
Affinity DataEC50:  1.12E+4nMAssay Description:SARS-CoV-2 CPE assay was conducted at Southern Research Institute (Birmingham, AL) as described in previous reports30, 31. In brief, high ACE2 expres...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails ArticlePubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
National Institutes Of Health

LigandPNGBDBM420331(AMG-837)
Affinity DataIC50:  2.42E+4nMAssay Description:The 3CLpro enzyme assay was developed in 384-well black, medium binding microplates (Greiner Bio-One, Monroe, NC, USA) with a total volume of 20 _...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails ArticlePubMed