BDBM421584 3-[5-(difluoromethyl)-1,3,4-thiadiazol-2-yl]-6-fluoro-N-[1-(fluoromethyl)cyclopropyl]-1-methyl-2-oxo-benzimidazole-5-sulfonamide::US10508086, Example 174::US10995073, Example 174

SMILES Cn1c2cc(F)c(cc2n(-c2nnc(s2)C(F)F)c1=O)S(=O)(=O)NC1(CF)CC1

InChI Key InChIKey=ITQSVBWAGTUWAZ-UHFFFAOYSA-N

Data  4 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 421584   

TargetPoly(ADP-ribose) glycohydrolase(Homo sapiens (Human))
Cancer Research Technology

US Patent
LigandPNGBDBM421584(3-[5-(difluoromethyl)-1,3,4-thiadiazol-2-yl]-6-flu...)
Affinity DataEC50:  91nMAssay Description:PARG In vitro assays were conducted in a total volume of 15 ul in a standard 384 well format. 5 ul of Human Full Length PARG (Produced internally by ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetADP-ribosylhydrolase ARH3(Homo sapiens (Human))
Cancer Research Technology

US Patent
LigandPNGBDBM421584(3-[5-(difluoromethyl)-1,3,4-thiadiazol-2-yl]-6-flu...)
Affinity DataIC50: >5.00E+4nMAssay Description:ARH3 In vitro selectivity assays were conducted in a total volume of 15 ul in a standard 384 well format. 5 ul of Human Full Length ARH3 (Enzo Life S...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Cancer Research Technology

US Patent
LigandPNGBDBM421584(3-[5-(difluoromethyl)-1,3,4-thiadiazol-2-yl]-6-flu...)
Affinity DataIC50: >1.50E+5nMAssay Description:PARP1 In vitro selectivity assays were conducted as a 10 ul reaction volume in a NUNC Maxisorp 384-well assay plate pre-coated in-house with Histones...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPoly(ADP-ribose) glycohydrolase(Homo sapiens (Human))
Cancer Research Technology

US Patent
LigandPNGBDBM421584(3-[5-(difluoromethyl)-1,3,4-thiadiazol-2-yl]-6-flu...)
Affinity DataEC50:  91nMAssay Description:PARG In vitro assays were conducted in a total volume of 15 ul in a standard 384 well format. 5 ul of Human Full Length PARG (Produced internally by ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetADP-ribosylhydrolase ARH3(Homo sapiens (Human))
Cancer Research Technology

US Patent
LigandPNGBDBM421584(3-[5-(difluoromethyl)-1,3,4-thiadiazol-2-yl]-6-flu...)
Affinity DataIC50: >5.00E+4nMAssay Description:ARH3 In vitro selectivity assays were conducted in a total volume of 15 ul in a standard 384 well format. 5 ul of Human Full Length ARH3 (Enzo Life S...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Cancer Research Technology

US Patent
LigandPNGBDBM421584(3-[5-(difluoromethyl)-1,3,4-thiadiazol-2-yl]-6-flu...)
Affinity DataIC50: >1.50E+5nMAssay Description:PARP1 In vitro selectivity assays were conducted as a 10 ul reaction volume in a NUNC Maxisorp 384-well assay plate pre-coated in-house with Histones...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent