BDBM423621 US10508120, Compound I-76::US10577373, Compound I-76::US11046698, Compound I-76

SMILES NC(=O)c1cnn2c(N)cc(Nc3cccn([C@@H]4CC[C@@H](CC4)N4CCOCC4)c3=O)nc12

InChI Key InChIKey=AYFJJSXLHKUJHG-GASCZTMLSA-N

Data  3 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 423621   

TargetNon-receptor tyrosine-protein kinase TYK2 [556-888](Homo sapiens (Human))
Nimbus Lakshimi

US Patent
LigandPNGBDBM423621(US10508120, Compound I-76 | US10577373, Compound I...)
Affinity DataKd:  5.5nMAssay Description:Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNon-receptor tyrosine-protein kinase TYK2 [556-888](Homo sapiens (Human))
Nimbus Lakshimi

US Patent
LigandPNGBDBM423621(US10508120, Compound I-76 | US10577373, Compound I...)
Affinity DataKd:  5.5nMAssay Description:Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNon-receptor tyrosine-protein kinase TYK2 [556-888](Homo sapiens (Human))
Nimbus Lakshimi

US Patent
LigandPNGBDBM423621(US10508120, Compound I-76 | US10577373, Compound I...)
Affinity DataKd:  5.5nMAssay Description:Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent