BDBM42528 (E)-3-(1-naphthalenyl)-1-pyridin-4-yl-2-propen-1-one::(E)-3-(1-naphthyl)-1-(4-pyridyl)prop-2-en-1-one::(E)-3-naphthalen-1-yl-1-pyridin-4-yl-prop-2-en-1-one::(E)-3-naphthalen-1-yl-1-pyridin-4-ylprop-2-en-1-one::3-(1-naphthyl)-1-(4-pyridinyl)-2-propen-1-one::MLS000573147::SMR000185081::cid_5338258

SMILES O=C(\C=C\c1cccc2ccccc12)c1ccncc1

InChI Key InChIKey=GCRUQDILILGFIY-CMDGGOBGSA-N

Data  15 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 15 hits for monomerid = 42528   

TargetNeuropeptide Y receptor type 1(Homo sapiens (Human))
The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay
LigandPNGBDBM42528((E)-3-(1-naphthalenyl)-1-pyridin-4-yl-2-propen-1-o...)
Affinity DataIC50:  5.47E+3nMAssay Description:Source (MLSCN Center Name): The Scripps Research Institute Molecular Screening Center Affiliation: The Scripps Research Institute, TSRI Assay Provide...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetCytochrome P450 1A2(Homo sapiens (Human))
De Montfort University

Curated by ChEMBL
LigandPNGBDBM42528((E)-3-(1-naphthalenyl)-1-pyridin-4-yl-2-propen-1-o...)
Affinity DataIC50:  28nMAssay Description:Inhibition of recombinant human CYP1A2 expressed in HEK293 cells using 3-cyano-7-ethoxycoumarin as substrate pretreated for 30 mins followed by subst...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
De Montfort University

Curated by ChEMBL
LigandPNGBDBM42528((E)-3-(1-naphthalenyl)-1-pyridin-4-yl-2-propen-1-o...)
Affinity DataIC50:  35nMAssay Description:Inhibition of human CYP1A2 expressed in yeast microsomal membranes using 3-cyano-7-ethoxycoumarin as substrate measured after 10 mins by fluorescence...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
De Montfort University

Curated by ChEMBL
LigandPNGBDBM42528((E)-3-(1-naphthalenyl)-1-pyridin-4-yl-2-propen-1-o...)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of human CYP2C19 expressed in yeast microsomal membranes using 3-cyano-7-ethoxycoumarin as substrate measured after 10 mins by fluorescenc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A1(Homo sapiens (Human))
De Montfort University

Curated by ChEMBL
LigandPNGBDBM42528((E)-3-(1-naphthalenyl)-1-pyridin-4-yl-2-propen-1-o...)
Affinity DataIC50:  550nMAssay Description:Inhibition of recombinant human CYP1A1 expressed in HEK293 cells using 7-ethoxyresorufin as substrate pretreated for 30 mins followed by substrate ad...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1B1(Homo sapiens (Human))
De Montfort University

Curated by ChEMBL
LigandPNGBDBM42528((E)-3-(1-naphthalenyl)-1-pyridin-4-yl-2-propen-1-o...)
Affinity DataIC50:  750nMAssay Description:Inhibition of recombinant human CYP1B1 expressed in HEK293 cells using 7-ethoxyresorufin as substrate pretreated for 30 mins followed by substrate ad...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
De Montfort University

Curated by ChEMBL
LigandPNGBDBM42528((E)-3-(1-naphthalenyl)-1-pyridin-4-yl-2-propen-1-o...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of recombinant human CYP2D6 expressed in HEK293 cells using 7-ethoxy-methyloxy-3-cyanocoumarin as substrate pretreated for 30 mins followe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
De Montfort University

Curated by ChEMBL
LigandPNGBDBM42528((E)-3-(1-naphthalenyl)-1-pyridin-4-yl-2-propen-1-o...)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of human CYP2C9 expressed in yeast microsomal membranes using 3-cyano-7-ethoxycoumarin as substrate measured after 10 mins by fluorescence...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
De Montfort University

Curated by ChEMBL
LigandPNGBDBM42528((E)-3-(1-naphthalenyl)-1-pyridin-4-yl-2-propen-1-o...)
Affinity DataIC50:  1.80E+4nMAssay Description:Inhibition of human CYP2D6 expressed in yeast microsomal membranes using 7-ethoxy-methyloxy-3-cyanocoumarin as substrate measured after 10 mins by fl...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1B1(Homo sapiens (Human))
De Montfort University

Curated by ChEMBL
LigandPNGBDBM42528((E)-3-(1-naphthalenyl)-1-pyridin-4-yl-2-propen-1-o...)
Affinity DataIC50:  650nMAssay Description:Inhibition of human CYP1B1 expressed in yeast microsomal membranes using 7-ethoxyresorufin as substrate measured after 10 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
De Montfort University

Curated by ChEMBL
LigandPNGBDBM42528((E)-3-(1-naphthalenyl)-1-pyridin-4-yl-2-propen-1-o...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of recombinant human CYP3A4 expressed in HEK293 cells using dibenzylfluorescein as substrate pretreated for 30 mins followed by substrate ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
De Montfort University

Curated by ChEMBL
LigandPNGBDBM42528((E)-3-(1-naphthalenyl)-1-pyridin-4-yl-2-propen-1-o...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of recombinant human CYP2C19 expressed in HEK293 cells using 3-cyano-7-ethoxycoumarin as substrate pretreated for 30 mins followed by subs...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
De Montfort University

Curated by ChEMBL
LigandPNGBDBM42528((E)-3-(1-naphthalenyl)-1-pyridin-4-yl-2-propen-1-o...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of recombinant human CYP2C9 expressed in HEK293 cells using 3-cyano-7-ethoxycoumarin as substrate pretreated for 30 mins followed by subst...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A1(Homo sapiens (Human))
De Montfort University

Curated by ChEMBL
LigandPNGBDBM42528((E)-3-(1-naphthalenyl)-1-pyridin-4-yl-2-propen-1-o...)
Affinity DataIC50:  510nMAssay Description:Inhibition of human CYP1A1 expressed in yeast microsomal membranes using 7-ethoxyresorufin as substrate measured after 10 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
De Montfort University

Curated by ChEMBL
LigandPNGBDBM42528((E)-3-(1-naphthalenyl)-1-pyridin-4-yl-2-propen-1-o...)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of human CYP3A4 expressed in yeast microsomal membranes using dibenzylfluorescein as substrate measured after 10 mins by fluorescence assa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed