BDBM4277 (3Z)-2-amino-3-(1H-indol-5-ylmethylidene)prop-1-ene-1,1,3-tricarbonitrile::Indole-Containing Inhibitor 2::Tyrphostin deriv. 7

SMILES N=C(C(C#N)C#N)C(=Cc1ccc2[nH]ccc2c1)C#N

InChI Key InChIKey=PEBPSCWSXYPIJD-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 4277   

TargetEpidermal growth factor receptor(Homo sapiens (Human))
Hebrew University Of Jerusalem

LigandPNGBDBM4277((3Z)-2-amino-3-(1H-indol-5-ylmethylidene)prop-1-en...)
Affinity DataIC50:  8.20E+5nMpH: 7.6 T: 2°CAssay Description:The activity of EGFR, preactivated with EGF, is measured by its ability to transfer terminal phosphate from [gamma-32P]ATP to poly(GAT) substrate.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
Hebrew University Of Jerusalem

LigandPNGBDBM4277((3Z)-2-amino-3-(1H-indol-5-ylmethylidene)prop-1-en...)
Affinity DataIC50:  1.00E+5nMAssay Description:The assay was using Swiss 3T3 cell membranes harboring EGF-R or PDGFR-beta. Receptor autophosphorylation was initiated by addition of [gamma-32P]ATP ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Hebrew University Of Jerusalem

LigandPNGBDBM4277((3Z)-2-amino-3-(1H-indol-5-ylmethylidene)prop-1-en...)
Affinity DataIC50:  1.00E+5nMpH: 7.5 T: 2°CAssay Description:The assay was using Swiss 3T3 cell membranes harboring EGF-R or PDGFR-beta. Receptor autophosphorylation was initiated by addition of [gamma-32P]ATP ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed