BDBM428533 US10544143, Example 969::US10730877, Example 969::US11053244, Example 969

SMILES CC(C)c1c([nH]c2ccc(nc12)N1CCN(CC1)C(=O)CN(C)CCO)-c1cn2ncnc2c(C)c1C

InChI Key InChIKey=NMYXJONXRIPQPV-UHFFFAOYSA-N

Data  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 428533   

TargetToll-like receptor 7(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM428533(US10544143, Example 969 | US10730877, Example 969 ...)
Affinity DataIC50:  1.30nMAssay Description:HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetToll-like receptor 8(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM428533(US10544143, Example 969 | US10730877, Example 969 ...)
Affinity DataIC50:  0.120nMAssay Description:HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetToll-like receptor 9(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM428533(US10544143, Example 969 | US10730877, Example 969 ...)
Affinity DataIC50:  7.18E+3nMAssay Description:HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetToll-like receptor 7(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM428533(US10544143, Example 969 | US10730877, Example 969 ...)
Affinity DataIC50:  1.30nMAssay Description:HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetToll-like receptor 9(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM428533(US10544143, Example 969 | US10730877, Example 969 ...)
Affinity DataIC50:  7.18E+3nMAssay Description:HEK-Blue™-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducibl...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetToll-like receptor 9(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM428533(US10544143, Example 969 | US10730877, Example 969 ...)
Affinity DataIC50:  7.18E+3nMAssay Description:HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetToll-like receptor 7(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM428533(US10544143, Example 969 | US10730877, Example 969 ...)
Affinity DataIC50:  1.30nMAssay Description:HEK-Blue™-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducibl...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetToll-like receptor 8(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM428533(US10544143, Example 969 | US10730877, Example 969 ...)
Affinity DataIC50:  0.120nMAssay Description:HEK-Blue™-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducibl...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetToll-like receptor 8(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM428533(US10544143, Example 969 | US10730877, Example 969 ...)
Affinity DataIC50:  0.120nMAssay Description:HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent