BDBM4295 (2E)-3-(3,4-dihydroxyphenyl)-2-[(4-methylphenyl)carbonyl]prop-2-enenitrile::Tyrphostin deriv. 28

SMILES Cc1ccc(cc1)C(=O)C(=C\c1ccc(O)c(O)c1)\C#N

InChI Key InChIKey=ZALNJTCOAIAQFA-RIYZIHGNSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 4295   

TargetEpidermal growth factor receptor(Homo sapiens (Human))
Hebrew University Of Jerusalem

LigandPNGBDBM4295((2E)-3-(3,4-dihydroxyphenyl)-2-[(4-methylphenyl)ca...)
Affinity DataIC50:  880nMAssay Description:The activity of EGFR, preactivated with EGF, is measured by its ability to transfer terminal phosphate from [gamma-32P]ATP to poly(GAT) substrate.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
University Of Tennessee Health Sciences Center

Curated by ChEMBL
LigandPNGBDBM4295((2E)-3-(3,4-dihydroxyphenyl)-2-[(4-methylphenyl)ca...)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibitory activity tested against protein kinase HER-2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Hebrew University Of Jerusalem

LigandPNGBDBM4295((2E)-3-(3,4-dihydroxyphenyl)-2-[(4-methylphenyl)ca...)
Affinity DataIC50:  1.51E+4nMAssay Description:Inhibitory activity against epidermal growth factor receptor (EGFR)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Hebrew University Of Jerusalem

LigandPNGBDBM4295((2E)-3-(3,4-dihydroxyphenyl)-2-[(4-methylphenyl)ca...)
Affinity DataIC50:  900nMAssay Description:Inhibition of EGFR in human A431 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed