BDBM429526 3-(5-Chloro-6-isobutoxypyridin-3-yl)-N-(cyclopropylsulfonyl)-5-fluoro-1-methyl-1H-indole-6-carboxamide::US10550080, Example 43

SMILES CC(C)COc1ncc(cc1Cl)-c1cn(C)c2cc(C(=O)NS(=O)(=O)C3CC3)c(F)cc12

InChI Key InChIKey=RUOURBQWRICTBV-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 429526   

TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM429526(3-(5-Chloro-6-isobutoxypyridin-3-yl)-N-(cyclopropy...)
Affinity DataIC50:  310nMAssay Description:Ion Works Barracuda population patch clamp (PPC). PPC measurements were performed using an IonWorks Barracuda instrument (Molecular Devices Corporati...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM429526(3-(5-Chloro-6-isobutoxypyridin-3-yl)-N-(cyclopropy...)
Affinity DataIC50:  3.40nMAssay Description:hNaV1.7 binding affinities were determined with a filtration binding assay using purified membranes from HEK293 cells stably expressing hNaV1.7. HEK2...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM429526(3-(5-Chloro-6-isobutoxypyridin-3-yl)-N-(cyclopropy...)
Affinity DataIC50:  4.85E+3nMAssay Description:Ion Works Barracuda population patch clamp (PPC). PPC measurements were performed using an IonWorks Barracuda instrument (Molecular Devices Corporati...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM429526(3-(5-Chloro-6-isobutoxypyridin-3-yl)-N-(cyclopropy...)
Affinity DataIC50:  3.30nMAssay Description:Inhibition of recombinant human Nav1.7 expressed in HEK293 cells at -70 mV holding potential by patch clamp electrophysiology methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM429526(3-(5-Chloro-6-isobutoxypyridin-3-yl)-N-(cyclopropy...)
Affinity DataIC50:  230nMAssay Description:Inhibition of human Nav1.7 expressed in HEK293 cells after 600 secs at -60 mV holding potential by ion works barracuda population patch clamp methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM429526(3-(5-Chloro-6-isobutoxypyridin-3-yl)-N-(cyclopropy...)
Affinity DataIC50:  5.10E+3nMAssay Description:Inhibition of human Nav1.5 expressed in HEK293 cells after 600 secs at -50 mV holding potential by ion works barracuda population patch clamp methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Mus musculus)
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM429526(3-(5-Chloro-6-isobutoxypyridin-3-yl)-N-(cyclopropy...)
Affinity DataIC50:  10nMAssay Description:Inhibition of recombinant mouse Nav1.7 expressed in HEK293 cells at -70 mV holding potential by patch clamp electrophysiology methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed