BDBM4297 (2E)-2-[(2-chlorophenyl)carbonyl]-3-(3,4-dihydroxyphenyl)prop-2-enenitrile::Tyrphostin deriv. 30

SMILES Oc1ccc(\C=C(/C#N)C(=O)c2ccccc2Cl)cc1O

InChI Key InChIKey=JVRJGQNWQLITMA-YRNVUSSQSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 4297   

TargetEpidermal growth factor receptor(Homo sapiens (Human))
Hebrew University Of Jerusalem

LigandPNGBDBM4297((2E)-2-[(2-chlorophenyl)carbonyl]-3-(3,4-dihydroxy...)
Affinity DataIC50:  1.54E+3nMAssay Description:The activity of EGFR, preactivated with EGF, is measured by its ability to transfer terminal phosphate from [gamma-32P]ATP to poly(GAT) substrate.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
University Of Tennessee Health Sciences Center

Curated by ChEMBL
LigandPNGBDBM4297((2E)-2-[(2-chlorophenyl)carbonyl]-3-(3,4-dihydroxy...)
Affinity DataIC50:  1.20E+4nMAssay Description:Inhibitory activity tested against protein kinase HER-2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Hebrew University Of Jerusalem

LigandPNGBDBM4297((2E)-2-[(2-chlorophenyl)carbonyl]-3-(3,4-dihydroxy...)
Affinity DataIC50:  6.61E+3nMAssay Description:Inhibitory activity against epidermal growth factor receptor (EGFR)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Hebrew University Of Jerusalem

LigandPNGBDBM4297((2E)-2-[(2-chlorophenyl)carbonyl]-3-(3,4-dihydroxy...)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of EGFR in human A431 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed