BDBM4306 (2E)-2-cyano-3-(3,4-dihydroxyphenyl)-N-(2-phenylethyl)prop-2-enamide::CHEMBL293749::Tyrphostin deriv. 52

SMILES Oc1ccc(\C=C(/C#N)C(=O)NCCc2ccccc2)cc1O

InChI Key InChIKey=ZZQHNBGRWRQWFI-XNTDXEJSSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 4306   

TargetEpidermal growth factor receptor(Homo sapiens (Human))
Hebrew University Of Jerusalem

LigandPNGBDBM4306((2E)-2-cyano-3-(3,4-dihydroxyphenyl)-N-(2-phenylet...)
Affinity DataIC50:  930nMAssay Description:The activity of EGFR, preactivated with EGF, is measured by its ability to transfer terminal phosphate from [gamma-32P]ATP to poly(GAT) substrate.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 1/2C(RAT)
University Of Oregon

Curated by ChEMBL
LigandPNGBDBM4306((2E)-2-cyano-3-(3,4-dihydroxyphenyl)-N-(2-phenylet...)
Affinity DataIC50: >1.00E+5nMAssay Description:Antagonistic activity against N-methyl-D-aspartate glutamate receptor 1/2C.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Rattus norvegicus (Rat))
University Of Oregon

Curated by ChEMBL
LigandPNGBDBM4306((2E)-2-cyano-3-(3,4-dihydroxyphenyl)-N-(2-phenylet...)
Affinity DataIC50:  1.70E+3nMAssay Description:Antagonistic activity against N-methyl-D-aspartate glutamate receptor 1/2B.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
University Of Tennessee Health Sciences Center

Curated by ChEMBL
LigandPNGBDBM4306((2E)-2-cyano-3-(3,4-dihydroxyphenyl)-N-(2-phenylet...)
Affinity DataIC50:  2.29E+4nMAssay Description:Inhibitory activity tested against protein kinase HER-2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 1/2A(Rattus norvegicus (Rat))
University Of Oregon

Curated by ChEMBL
LigandPNGBDBM4306((2E)-2-cyano-3-(3,4-dihydroxyphenyl)-N-(2-phenylet...)
Affinity DataIC50: >1.00E+5nMAssay Description:Antagonistic activity against N-methyl-D-aspartate glutamate receptor 1/2A.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Hebrew University Of Jerusalem

LigandPNGBDBM4306((2E)-2-cyano-3-(3,4-dihydroxyphenyl)-N-(2-phenylet...)
Affinity DataIC50:  900nMAssay Description:Inhibition of EGFR in human A431 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Hebrew University Of Jerusalem

LigandPNGBDBM4306((2E)-2-cyano-3-(3,4-dihydroxyphenyl)-N-(2-phenylet...)
Affinity DataIC50:  617nMAssay Description:Inhibitory activity against epidermal growth factor receptor (EGFR)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
University Of Tennessee Health Sciences Center

Curated by ChEMBL
LigandPNGBDBM4306((2E)-2-cyano-3-(3,4-dihydroxyphenyl)-N-(2-phenylet...)
Affinity DataIC50:  2.30E+4nMAssay Description:Inhibition of ERBB2 receptor autophosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed