BDBM4310 (2E)-2-cyano-N-cyclohexyl-3-(3,4-dihydroxyphenyl)prop-2-enamide::Tyrphostin deriv. 60

SMILES Oc1ccc(\C=C(/C#N)C(=O)NC2CCCCC2)cc1O

InChI Key InChIKey=XMFXBOGXTNAKKW-XYOKQWHBSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 4310   

TargetEpidermal growth factor receptor(Homo sapiens (Human))
Hebrew University Of Jerusalem

LigandPNGBDBM4310((2E)-2-cyano-N-cyclohexyl-3-(3,4-dihydroxyphenyl)p...)
Affinity DataIC50:  1.60E+3nMAssay Description:The activity of EGFR, preactivated with EGF, is measured by its ability to transfer terminal phosphate from [gamma-32P]ATP to poly(GAT) substrate.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Hebrew University Of Jerusalem

LigandPNGBDBM4310((2E)-2-cyano-N-cyclohexyl-3-(3,4-dihydroxyphenyl)p...)
Affinity DataIC50:  5.89E+3nMAssay Description:Inhibitory activity against epidermal growth factor receptor (EGFR)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
University Of Tennessee Health Sciences Center

Curated by ChEMBL
LigandPNGBDBM4310((2E)-2-cyano-N-cyclohexyl-3-(3,4-dihydroxyphenyl)p...)
Affinity DataIC50:  1.70E+4nMAssay Description:Inhibitory activity tested against protein kinase HER-2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed