BDBM431622 US10550105, Example 545B::US10550105, Example 545C::US10870641, Example 545C::US11014913, Example 545C

SMILES FC(F)(F)c1ccc(nc1)N1CCN(CC1)C(=O)C[C@H]1CC[C@H](COc2cn[nH]c(=O)c2C(F)(F)F)O1

InChI Key

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 431622   

TargetProtein mono-ADP-ribosyltransferase TIPARP(Human)
Ribon Therapeutics

US Patent
LigandPNGBDBM431622(US10550105, Example 545B | US10550105, Example 545...)
Affinity DataIC50:  550nMAssay Description:Displacement of Probe A, a biotinylated probe binding to the TIPARP active site, was measured using a time-resolved fluorescence energy transfer (TR-...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProtein mono-ADP-ribosyltransferase TIPARP(Human)
Ribon Therapeutics

US Patent
LigandPNGBDBM431622(US10550105, Example 545B | US10550105, Example 545...)
Affinity DataIC50: <100nMAssay Description:Displacement of Probe A, a biotinylated probe binding to the TIPARP active site, was measured using a time-resolved fluorescence energy transfer (TR-...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProtein mono-ADP-ribosyltransferase TIPARP(Human)
Ribon Therapeutics

US Patent
LigandPNGBDBM431622(US10550105, Example 545B | US10550105, Example 545...)
Affinity DataIC50: <100nMAssay Description:Displacement of Probe A, a biotinylated probe binding to the TIPARP active site, was measured using a time-resolved fluorescence energy transfer (TR-...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProtein mono-ADP-ribosyltransferase TIPARP(Human)
Ribon Therapeutics

US Patent
LigandPNGBDBM431622(US10550105, Example 545B | US10550105, Example 545...)
Affinity DataIC50: <100nMAssay Description:Displacement of Probe A, a biotinylated probe binding to the TIPARP active site, was measured using a time-resolved fluorescence energy transfer (TR-...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent