BDBM43524 4-(4-fluorophenyl)-2-(methylsulfonyl)-6-(trifluoromethyl)pyrimidine::4-(4-fluorophenyl)-2-mesyl-6-(trifluoromethyl)pyrimidine::4-(4-fluorophenyl)-2-methylsulfonyl-6-(trifluoromethyl)pyrimidine::MLS000675919::SMR000297077::cid_2987363

SMILES CS(=O)(=O)c1nc(cc(n1)C(F)(F)F)-c1ccc(F)cc1

InChI Key InChIKey=FABYEEIARBZBHO-UHFFFAOYSA-N

Data  10 IC50

Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 43524   

TargetSignal transducer and activator of transcription 3 [702-738,740-752](Homo sapiens (Human))
The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay
LigandPNGBDBM43524(4-(4-fluorophenyl)-2-(methylsulfonyl)-6-(trifluoro...)
Show SMILES CS(=O)(=O)c1nc(cc(n1)C(F)(F)F)-c1ccc(F)cc1
Show InChI InChI=1S/C12H8F4N2O2S/c1-21(19,20)11-17-9(6-10(18-11)12(14,15)16)7-2-4-8(13)5-3-7/h2-6H,1H3
Affinity DataIC50: 2.38E+4nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center Center Affiliation: The Scripps Research Institute (TSRI) Assay...More data for this Ligand-Target Pair
TargetSignal transducer and activator of transcription 1-alpha/beta(Homo sapiens (Human))
The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay
LigandPNGBDBM43524(4-(4-fluorophenyl)-2-(methylsulfonyl)-6-(trifluoro...)
Show SMILES CS(=O)(=O)c1nc(cc(n1)C(F)(F)F)-c1ccc(F)cc1
Show InChI InChI=1S/C12H8F4N2O2S/c1-21(19,20)11-17-9(6-10(18-11)12(14,15)16)7-2-4-8(13)5-3-7/h2-6H,1H3
Affinity DataIC50: 1.21E+4nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center Center Affiliation: The Scripps Research Institute (TSRI) Assay...More data for this Ligand-Target Pair
TargetDNA damage-inducible transcript 3 protein(Mus musculus)
Emory University

Curated by PubChem BioAssay
LigandPNGBDBM43524(4-(4-fluorophenyl)-2-(methylsulfonyl)-6-(trifluoro...)
Show SMILES CS(=O)(=O)c1nc(cc(n1)C(F)(F)F)-c1ccc(F)cc1
Show InChI InChI=1S/C12H8F4N2O2S/c1-21(19,20)11-17-9(6-10(18-11)12(14,15)16)7-2-4-8(13)5-3-7/h2-6H,1H3
Affinity DataIC50: 2.44E+3nMAssay Description:NIH Molecular Libraries Screening Centers Network [MLSCN] Emory Chemical Biology Discovery Center in MLSCN Assay provider: Dr. Randal Kaufman, Univer...More data for this Ligand-Target Pair
TargetX-box-binding protein 1(Homo sapiens (Human))
Emory University

Curated by PubChem BioAssay
LigandPNGBDBM43524(4-(4-fluorophenyl)-2-(methylsulfonyl)-6-(trifluoro...)
Show SMILES CS(=O)(=O)c1nc(cc(n1)C(F)(F)F)-c1ccc(F)cc1
Show InChI InChI=1S/C12H8F4N2O2S/c1-21(19,20)11-17-9(6-10(18-11)12(14,15)16)7-2-4-8(13)5-3-7/h2-6H,1H3
Affinity DataIC50: 1.00E+4nMAssay Description:NIH Molecular Libraries Screening Centers Network [MLSCN] Emory Chemical Biology Discovery Center in MLSCN Assay provider: Dr. Randal Kaufman, Univer...More data for this Ligand-Target Pair
TargetGalanin receptor type 3(Homo sapiens (Human))
The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay
LigandPNGBDBM43524(4-(4-fluorophenyl)-2-(methylsulfonyl)-6-(trifluoro...)
Show SMILES CS(=O)(=O)c1nc(cc(n1)C(F)(F)F)-c1ccc(F)cc1
Show InChI InChI=1S/C12H8F4N2O2S/c1-21(19,20)11-17-9(6-10(18-11)12(14,15)16)7-2-4-8(13)5-3-7/h2-6H,1H3
Affinity DataIC50: 2.99E+4nMMore data for this Ligand-Target Pair
TargetToll-like receptor 9(Homo sapiens (Human))
The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay
LigandPNGBDBM43524(4-(4-fluorophenyl)-2-(methylsulfonyl)-6-(trifluoro...)
Show SMILES CS(=O)(=O)c1nc(cc(n1)C(F)(F)F)-c1ccc(F)cc1
Show InChI InChI=1S/C12H8F4N2O2S/c1-21(19,20)11-17-9(6-10(18-11)12(14,15)16)7-2-4-8(13)5-3-7/h2-6H,1H3
Affinity DataIC50: 1.37E+4nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Affiliation: The Scripps Research Institute, TSRI Assa...More data for this Ligand-Target Pair
TargetBeta-lactamase(Pseudomonas aeruginosa)
The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay
LigandPNGBDBM43524(4-(4-fluorophenyl)-2-(methylsulfonyl)-6-(trifluoro...)
Show SMILES CS(=O)(=O)c1nc(cc(n1)C(F)(F)F)-c1ccc(F)cc1
Show InChI InChI=1S/C12H8F4N2O2S/c1-21(19,20)11-17-9(6-10(18-11)12(14,15)16)7-2-4-8(13)5-3-7/h2-6H,1H3
Affinity DataIC50: 2.74E+4nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Affiliation: The Scripps Research Institute, TSRI Assa...More data for this Ligand-Target Pair
TargetBeta-lactamase(Pseudomonas aeruginosa)
The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay
LigandPNGBDBM43524(4-(4-fluorophenyl)-2-(methylsulfonyl)-6-(trifluoro...)
Show SMILES CS(=O)(=O)c1nc(cc(n1)C(F)(F)F)-c1ccc(F)cc1
Show InChI InChI=1S/C12H8F4N2O2S/c1-21(19,20)11-17-9(6-10(18-11)12(14,15)16)7-2-4-8(13)5-3-7/h2-6H,1H3
Affinity DataIC50: 1.77E+4nMMore data for this Ligand-Target Pair
TargetReceptor-interacting serine/threonine-protein kinase 2(Homo sapiens (Human))
The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay
LigandPNGBDBM43524(4-(4-fluorophenyl)-2-(methylsulfonyl)-6-(trifluoro...)
Show SMILES CS(=O)(=O)c1nc(cc(n1)C(F)(F)F)-c1ccc(F)cc1
Show InChI InChI=1S/C12H8F4N2O2S/c1-21(19,20)11-17-9(6-10(18-11)12(14,15)16)7-2-4-8(13)5-3-7/h2-6H,1H3
Affinity DataIC50: 2.79E+3nMMore data for this Ligand-Target Pair
TargetDNA damage-inducible transcript 3 protein(Mus musculus)
Emory University

Curated by PubChem BioAssay
LigandPNGBDBM43524(4-(4-fluorophenyl)-2-(methylsulfonyl)-6-(trifluoro...)
Show SMILES CS(=O)(=O)c1nc(cc(n1)C(F)(F)F)-c1ccc(F)cc1
Show InChI InChI=1S/C12H8F4N2O2S/c1-21(19,20)11-17-9(6-10(18-11)12(14,15)16)7-2-4-8(13)5-3-7/h2-6H,1H3
Affinity DataIC50: 2.44E+3nMAssay Description:NIH Molecular Libraries Screening Centers Network [MLSCN] Emory Chemical Biology Discovery Center in MLSCN Assay provider: Dr. Randal Kaufman, Univer...More data for this Ligand-Target Pair