BDBM447658 (3aR,6aR)-5-cyano-N-(2- fluoro-4-(trifluoromethoxy) phenyl)hexahydropyrrolo [3,4-b]pyrrole-1(2H)- carboxamide::US10689345, Example 197::US11066365, Example 197::US11390584, Example 197

SMILES Fc1cc(OC(F)(F)F)ccc1NC(=O)N1CC[C@@H]2CN(C[C@H]12)C#N

InChI Key InChIKey=DDFGJQDAKCUHFI-RNCFNFMXSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 447658   

TargetUbiquitin carboxyl-terminal hydrolase 30(Homo sapiens (Human))
Mission Therapeutics

US Patent
LigandPNGBDBM447658((3aR,6aR)-5-cyano-N-(2- fluoro-4-(trifluoromethoxy...)
Affinity DataIC50: <100nMAssay Description:USP30 Biochemical Fluorescence Intensity Kinetic Assay.Reactions were performed in duplicate in black 384 well plates (small volume, Greiner 784076) ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetUbiquitin carboxyl-terminal hydrolase 30(Homo sapiens (Human))
Mission Therapeutics

US Patent
LigandPNGBDBM447658((3aR,6aR)-5-cyano-N-(2- fluoro-4-(trifluoromethoxy...)
Affinity DataIC50: <100nMAssay Description:Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetUbiquitin carboxyl-terminal hydrolase 30(Homo sapiens (Human))
Mission Therapeutics

US Patent
LigandPNGBDBM447658((3aR,6aR)-5-cyano-N-(2- fluoro-4-(trifluoromethoxy...)
Affinity DataIC50: <100nMAssay Description:USP30 biochemical fluorescence intensity IC50 assay Dilution plates were prepared at 21 times the final concentration (2100 μM for a final conce...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent