BDBM4635 2-chloro-4-fluoro-5-{[6-methoxy-7-(2-methoxyethoxy)cinnolin-4-yl]amino}phenol::4-anilinocinnoline deriv. 18::CHEMBL150826::KDR Kinase Inhibitor, 6

SMILES COCCOc1cc2nncc(Nc3cc(O)c(Cl)cc3F)c2cc1OC

InChI Key InChIKey=JDPAKZCGVWMFFH-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 4635   

TargetVascular endothelial growth factor receptor 1(Homo sapiens (Human))
Astrazeneca

LigandPNGBDBM4635(2-chloro-4-fluoro-5-{[6-methoxy-7-(2-methoxyethoxy...)
Affinity DataIC50:  50nMpH: 7.4 T: 2°CAssay Description:An ELISA assay was used to determine the ability of inhibitor to inhibit VEGF-R RTK activity. The compounds were incubated with enzyme 20 min at room...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Astrazeneca

LigandPNGBDBM4635(2-chloro-4-fluoro-5-{[6-methoxy-7-(2-methoxyethoxy...)
Affinity DataIC50:  4nMT: 2°CAssay Description:An ELISA assay was used to determine the ability of inhibitor to inhibit VEGF-R RTK activity. The compounds were incubated with enzyme 20 min at room...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Astrazeneca

LigandPNGBDBM4635(2-chloro-4-fluoro-5-{[6-methoxy-7-(2-methoxyethoxy...)
Affinity DataIC50:  4nMAssay Description:Inhibition of KDRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Astrazeneca

LigandPNGBDBM4635(2-chloro-4-fluoro-5-{[6-methoxy-7-(2-methoxyethoxy...)
Affinity DataIC50:  4nMAssay Description:Inhibition assay using KDR.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Astrazeneca

LigandPNGBDBM4635(2-chloro-4-fluoro-5-{[6-methoxy-7-(2-methoxyethoxy...)
Affinity DataIC50: >3.30E+4nMT: 2°CAssay Description:An ELISA assay was used to determine the ability of inhibitor to inhibit FGFR-1 TK activity. The compounds were incubated with enzyme 20 min at room ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed