BDBM464418 US10787457, Example 51::US11014930, Example 51::US11236096, Example 51

SMILES Cc1cc(NC(=O)c2cn(c3ncnc(N)c23)C2(C)CC2)n[nH]1

InChI Key InChIKey=VKNSWNWSJODLGL-UHFFFAOYSA-N

Data  5 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 464418   

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
Taiho Pharmaceutical

US Patent
LigandPNGBDBM464418(US10787457, Example 51 | US11014930, Example 51 | ...)
Affinity DataIC50:  0.170nMAssay Description:To measure the inhibitory activity, first, the compounds of the present invention were individually diluted with dimethyl sulfoxide (DMSO) stepwise. ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
Taiho Pharmaceutical

US Patent
LigandPNGBDBM464418(US10787457, Example 51 | US11014930, Example 51 | ...)
Affinity DataIC50:  0.170nMAssay Description:To measure the inhibitory activity, first, the compounds of the present invention were individually diluted with dimethyl sulfoxide (DMSO) stepwise. ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Taiho Pharmaceutical

US Patent
LigandPNGBDBM464418(US10787457, Example 51 | US11014930, Example 51 | ...)
Affinity DataIC50:  1.22E+3nMAssay Description:Regarding the conditions for measurement of in vitro inhibitory activity of compounds against LCK kinase activity, the website of AnaSpec states that...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails US Patent
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Taiho Pharmaceutical

US Patent
LigandPNGBDBM464418(US10787457, Example 51 | US11014930, Example 51 | ...)
Affinity DataIC50:  8.70nMAssay Description:Regarding the conditions for measurement of in vitro inhibitory activity of compounds against SRC kinase activity, the price list of LabChip-series c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails US Patent
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
Taiho Pharmaceutical

US Patent
LigandPNGBDBM464418(US10787457, Example 51 | US11014930, Example 51 | ...)
Affinity DataIC50:  0.170nMAssay Description:Regarding the conditions for measurement of in vitro inhibitory activity of compounds against RET kinase activity, the website of AnaSpec states that...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB