BDBM4659 4-Anilinoquinazoline 6::N-(4-Chloro-2-fluorophenyl)-6-methoxy-7-[2-(4-methylpiperazin-1-yl)ethoxy]quinazolin-4-amine

SMILES COc1cc2c(Nc3ccc(Cl)cc3F)ncnc2cc1OCCN1CCN(C)CC1

InChI Key InChIKey=GSFNVLNOUTVLFC-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 4659   

TargetVascular endothelial growth factor receptor 1(Homo sapiens (Human))
Astrazeneca

LigandPNGBDBM4659(4-Anilinoquinazoline 6 | N-(4-Chloro-2-fluoropheny...)
Affinity DataIC50:  300nMpH: 7.4 T: 2°CAssay Description:An ELISA assay was used to determine the ability of inhibitor to inhibit VEGF-R RTK activity. The compounds were incubated with enzyme 20 min at room...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Astrazeneca

LigandPNGBDBM4659(4-Anilinoquinazoline 6 | N-(4-Chloro-2-fluoropheny...)
Affinity DataIC50:  200nMT: 2°CAssay Description:An ELISA assay was used to determine the ability of inhibitor to inhibit EGF-R RTK activity. The compounds were incubated with enzyme 20 min at room ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Astrazeneca

LigandPNGBDBM4659(4-Anilinoquinazoline 6 | N-(4-Chloro-2-fluoropheny...)
Affinity DataIC50:  8.00E+3nMT: 2°CAssay Description:An ELISA assay was used to determine the ability of inhibitor to inhibit FGFR-1 TK activity. The compounds were incubated with enzyme 20 min at room ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Astrazeneca

LigandPNGBDBM4659(4-Anilinoquinazoline 6 | N-(4-Chloro-2-fluoropheny...)
Affinity DataIC50:  30nMT: 2°CAssay Description:An ELISA assay was used to determine the ability of inhibitor to inhibit VEGF-R RTK activity. The compounds were incubated with enzyme 20 min at room...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed