BDBM466547 US10800755, Example 4::US11014905, Example 4

SMILES Cc1cccc(n1)C1CCN(CCNC(=O)C2CCC(F)(F)CC2)CC1

InChI Key InChIKey=KQNGZWUJPKEOIL-UHFFFAOYSA-N

Data  3 KI  4 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 466547   

TargetD(2) dopamine receptor(Homo sapiens (Human))
Sumitomo Dainippon Pharma

US Patent
LigandPNGBDBM466547(US10800755, Example 4 | US11014905, Example 4)
Affinity DataKi:  0.400nMAssay Description:The binding affinity of the present compounds to human 5-HT1A receptor, human D4 receptor, and human D2 receptor was measured in a manner mentioned b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetD(4) dopamine receptor(Homo sapiens (Human))
Sumitomo Dainippon Pharma

US Patent
LigandPNGBDBM466547(US10800755, Example 4 | US11014905, Example 4)
Affinity DataKi:  26nMAssay Description:The binding affinity of the present compounds to human 5-HT1A receptor, human D4 receptor, and human D2 receptor was measured in a manner mentioned b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Sumitomo Dainippon Pharma

US Patent
LigandPNGBDBM466547(US10800755, Example 4 | US11014905, Example 4)
Affinity DataKi: >1.00E+4nMAssay Description:The binding affinity of the present compounds to human 5-HT1A receptor, human D4 receptor, and human D2 receptor was measured in a manner mentioned b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Sumitomo Dainippon Pharma

US Patent
LigandPNGBDBM466547(US10800755, Example 4 | US11014905, Example 4)
Affinity DataIC50:  4.00E+3nMAssay Description:The activity of the present compound for inhibiting hERG channel was measured by whole-cell patch clamp method with auto patch clamp system, using CH...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetD(4) dopamine receptor(Homo sapiens (Human))
Sumitomo Dainippon Pharma

US Patent
LigandPNGBDBM466547(US10800755, Example 4 | US11014905, Example 4)
Affinity DataEC50:  25.1nMAssay Description:Aequorin, Gα16 proteins, and each receptor were transiently expressed in CHO-K1 cell (Chinese hamster ovary), and seeded to 384-well plate. The ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetD(2) dopamine receptor(Homo sapiens (Human))
Sumitomo Dainippon Pharma

US Patent
LigandPNGBDBM466547(US10800755, Example 4 | US11014905, Example 4)
Affinity DataIC50: >1.00E+4nMAssay Description:The binding affinity of the present compounds to human 5-HT1A receptor, human D4 receptor, and human D2 receptor was measured in a manner mentioned b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetD(4) dopamine receptor(Homo sapiens (Human))
Sumitomo Dainippon Pharma

US Patent
LigandPNGBDBM466547(US10800755, Example 4 | US11014905, Example 4)
Affinity DataIC50:  26nMAssay Description:The binding affinity of the present compounds to human 5-HT1A receptor, human D4 receptor, and human D2 receptor was measured in a manner mentioned b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Sumitomo Dainippon Pharma

US Patent
LigandPNGBDBM466547(US10800755, Example 4 | US11014905, Example 4)
Affinity DataIC50:  0.400nMAssay Description:The binding affinity of the present compounds to human 5-HT1A receptor, human D4 receptor, and human D2 receptor was measured in a manner mentioned b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Sumitomo Dainippon Pharma

US Patent
LigandPNGBDBM466547(US10800755, Example 4 | US11014905, Example 4)
Affinity DataEC50: <10nMAssay Description:Aequorin, Gα16 proteins, and each receptor were transiently expressed in CHO-K1 cell (Chinese hamster ovary), and seeded to 384-well plate. The ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent