BDBM4681 4-Anilinoquinazoline 28::N-(4-Bromo-2-fluorophenyl)-6-methoxy-7-(piperidin-4-ylmethoxy)quinazolin-4-amine::N-(4-bromo-2-fluorophenyl)-6-methoxy-7-[2-(piperidin-4-yl)ethoxy]quinazolin-4-amine

SMILES COc1cc2c(Nc3ccc(Br)cc3F)ncnc2cc1OCCC1CCNCC1

InChI Key InChIKey=ZESRALQQFCOMOY-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 4681   

TargetVascular endothelial growth factor receptor 1(Homo sapiens (Human))
Astrazeneca

LigandPNGBDBM4681(4-Anilinoquinazoline 28 | N-(4-Bromo-2-fluoropheny...)
Affinity DataIC50:  200nMT: 2°CAssay Description:An ELISA assay was used to determine the ability of inhibitor to inhibit VEGF-R RTK activity. The compounds were incubated with enzyme 20 min at room...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Astrazeneca

LigandPNGBDBM4681(4-Anilinoquinazoline 28 | N-(4-Bromo-2-fluoropheny...)
Affinity DataIC50:  200nMT: 2°CAssay Description:An ELISA assay was used to determine the ability of inhibitor to inhibit EGF-R RTK activity. The compounds were incubated with enzyme 20 min at room ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Astrazeneca

LigandPNGBDBM4681(4-Anilinoquinazoline 28 | N-(4-Bromo-2-fluoropheny...)
Affinity DataIC50:  2.70E+3nMT: 2°CAssay Description:An ELISA assay was used to determine the ability of inhibitor to inhibit FGFR-1 TK activity. The compounds were incubated with enzyme 20 min at room ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Astrazeneca

LigandPNGBDBM4681(4-Anilinoquinazoline 28 | N-(4-Bromo-2-fluoropheny...)
Affinity DataIC50:  40nMT: 2°CAssay Description:An ELISA assay was used to determine the ability of inhibitor to inhibit VEGF-R RTK activity. The compounds were incubated with enzyme 20 min at room...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed