BDBM47167 CHEMBL201511::US8957103, Z1::US9364459, A
SMILES COc1cc(cc(OC)c1OC)C1=C(C(=O)NC1=O)c1c[nH]c2ccccc12
InChI Key InChIKey=CZGMEOAMQWAJOY-UHFFFAOYSA-N
Data 61 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 61 hits for monomerid = 47167
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Johannes Gutenberg—Universitat Mainz
US Patent
Johannes Gutenberg—Universitat Mainz
US Patent
Affinity DataIC50: 90nMAssay Description:The effect of test compounds on the activity of the protein kinases GSK-3β, VEGFR-2 and FLT-3 was evaluated based on half maximal inhibitory con...More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Johannes Gutenberg—Universitat Mainz
US Patent
Johannes Gutenberg—Universitat Mainz
US Patent
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Johannes Gutenberg—Universitat Mainz
US Patent
Johannes Gutenberg—Universitat Mainz
US Patent
Affinity DataIC50: >1.00E+3nMAssay Description:The effect of test compounds on the activity of the protein kinases GSK-3β, VEGFR-2 and FLT-3 was evaluated based on half maximal inhibitory con...More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Johannes Gutenberg—Universitat Mainz
US Patent
Johannes Gutenberg—Universitat Mainz
US Patent
Affinity DataIC50: 90nMAssay Description:The effect of test compounds on the activity of the protein kinases GSK-3β, VEGFR-2 and FLT-3 was evaluated based on half maximal inhibitory con...More data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Johannes Gutenberg-UniversitäT Mainz
US Patent
Johannes Gutenberg-UniversitäT Mainz
US Patent
Affinity DataIC50: 166nMAssay Description:The effect of test compounds on the activity of the protein kinases GSK-3β, VEGFR-2 and FLT-3 was evaluated based on half maximal inhibitory con...More data for this Ligand-Target Pair
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Johannes Gutenberg—Universitat Mainz
US Patent
Johannes Gutenberg—Universitat Mainz
US Patent
Affinity DataIC50: 1.10E+3nMAssay Description:The effect of test compounds on the activity of the protein kinases GSK-3β, VEGFR-2 and FLT-3 was evaluated based on half maximal inhibitory con...More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 3(Homo sapiens (Human))
Eberhard-Karls University
Curated by ChEMBL
Eberhard-Karls University
Curated by ChEMBL
Affinity DataIC50: 5nMAssay Description:Inhibition of human VEGFR3More data for this Ligand-Target Pair
Affinity DataIC50: 2.30E+4nMAssay Description:Inhibition of human Ins-RMore data for this Ligand-Target Pair
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of human Aurora-BMore data for this Ligand-Target Pair
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Eberhard-Karls University
Curated by ChEMBL
Eberhard-Karls University
Curated by ChEMBL
Affinity DataIC50: 9.90E+3nMAssay Description:Inhibition of human CDK4 (with cyclin D1)More data for this Ligand-Target Pair
Affinity DataIC50: 1.70E+4nMAssay Description:Inhibition of human recombinant Aurora BMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 3(Homo sapiens (Human))
Eberhard-Karls University
Curated by ChEMBL
Eberhard-Karls University
Curated by ChEMBL
Affinity DataIC50: 5nMAssay Description:Inhibition of human recombinant VEGFR3More data for this Ligand-Target Pair
Affinity DataIC50: 1.60E+4nMAssay Description:Inhibition of human recombinant INS-RMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 3(Homo sapiens (Human))
Eberhard-Karls University
Curated by ChEMBL
Eberhard-Karls University
Curated by ChEMBL
Affinity DataIC50: 22nMAssay Description:Inhibition of VEGFR3 after 80 mins by radiometric protein kinase assayMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Johannes Gutenberg—Universitat Mainz
US Patent
Johannes Gutenberg—Universitat Mainz
US Patent
Affinity DataIC50: 2.5nMAssay Description:Inhibition of human VEGFR2More data for this Ligand-Target Pair
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Eberhard-Karls University
Curated by ChEMBL
Eberhard-Karls University
Curated by ChEMBL
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human AKT1More data for this Ligand-Target Pair
Affinity DataIC50: 9.30E+4nMAssay Description:Inhibition of human ABL1More data for this Ligand-Target Pair
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Eberhard-Karls University
Curated by ChEMBL
Eberhard-Karls University
Curated by ChEMBL
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of human ERbB2More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase Nek2(Homo sapiens (Human))
Eberhard-Karls University
Curated by ChEMBL
Eberhard-Karls University
Curated by ChEMBL
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human NEK2More data for this Ligand-Target Pair
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Eberhard-Karls University
Curated by ChEMBL
Eberhard-Karls University
Curated by ChEMBL
Affinity DataIC50: 9.90E+3nMAssay Description:Inhibition of human IGF1-RMore data for this Ligand-Target Pair
Affinity DataIC50: 1.60E+4nMAssay Description:Inhibition of human EPHB4More data for this Ligand-Target Pair
Affinity DataIC50: 2.80E+3nMAssay Description:Inhibition of human TIE2More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Eberhard-Karls University
Curated by ChEMBL
Eberhard-Karls University
Curated by ChEMBL
Affinity DataIC50: 3.20E+4nMAssay Description:Inhibition of human EGFRMore data for this Ligand-Target Pair
TargetCyclin-A1/Cyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Eberhard-Karls University
Curated by ChEMBL
Eberhard-Karls University
Curated by ChEMBL
Affinity DataIC50: 8.20E+3nMAssay Description:Inhibition of human CDK2 (with cyclin A)More data for this Ligand-Target Pair
Affinity DataIC50: 9.90E+3nMAssay Description:Inhibition of human Aurora-AMore data for this Ligand-Target Pair
TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
Eberhard-Karls University
Curated by ChEMBL
Eberhard-Karls University
Curated by ChEMBL
Affinity DataIC50: 680nMAssay Description:Inhibition of human PDGFR betaMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Johannes Gutenberg—Universitat Mainz
US Patent
Johannes Gutenberg—Universitat Mainz
US Patent
Affinity DataIC50: 2.5nMAssay Description:Inhibition of human VEGFR2More data for this Ligand-Target Pair
Affinity DataIC50: 970nMAssay Description:Inhibition of human FAKMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase PLK1(Homo sapiens (Human))
Eberhard-Karls University
Curated by ChEMBL
Eberhard-Karls University
Curated by ChEMBL
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human PLK1More data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Eberhard-Karls University
Curated by ChEMBL
Eberhard-Karls University
Curated by ChEMBL
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of human SRCMore data for this Ligand-Target Pair
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Johannes Gutenberg—Universitat Mainz
US Patent
Johannes Gutenberg—Universitat Mainz
US Patent
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of human GSK3 betaMore data for this Ligand-Target Pair
TargetNUAK family SNF1-like kinase 1(Homo sapiens (Human))
Eberhard-Karls University
Curated by ChEMBL
Eberhard-Karls University
Curated by ChEMBL
Affinity DataIC50: 4.30E+4nMAssay Description:Inhibition of human recombinant ARK5More data for this Ligand-Target Pair
Affinity DataIC50: 5.40E+3nMAssay Description:Inhibition of human recombinant Aurora AMore data for this Ligand-Target Pair
Affinity DataIC50: 6.90E+3nMAssay Description:Inhibition of human recombinant CDK2/cyclin AMore data for this Ligand-Target Pair
Affinity DataIC50: 1.40E+4nMAssay Description:Inhibition of human recombinant CDK4/cyclin D1More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Eberhard-Karls University
Curated by ChEMBL
Eberhard-Karls University
Curated by ChEMBL
Affinity DataIC50: 1.60E+4nMAssay Description:Inhibition of human recombinant EGFRMore data for this Ligand-Target Pair
Affinity DataIC50: 5.10E+3nMAssay Description:Inhibition of human recombinant EPHB4More data for this Ligand-Target Pair
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Eberhard-Karls University
Curated by ChEMBL
Eberhard-Karls University
Curated by ChEMBL
Affinity DataIC50: 2.60E+4nMAssay Description:Inhibition of human recombinant ERBB2More data for this Ligand-Target Pair
Affinity DataIC50: 650nMAssay Description:Inhibition of human recombinant FAKMore data for this Ligand-Target Pair
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Eberhard-Karls University
Curated by ChEMBL
Eberhard-Karls University
Curated by ChEMBL
Affinity DataIC50: 1.30E+4nMAssay Description:Inhibition of human recombinant IGF1RMore data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Eberhard-Karls University
Curated by ChEMBL
Eberhard-Karls University
Curated by ChEMBL
Affinity DataIC50: 2.10E+4nMAssay Description:Inhibition of human recombinant SRCMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Johannes Gutenberg—Universitat Mainz
US Patent
Johannes Gutenberg—Universitat Mainz
US Patent
Affinity DataIC50: 2.5nMAssay Description:Inhibition of human recombinant VEGFR2More data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Johannes Gutenberg-UniversitäT Mainz
US Patent
Johannes Gutenberg-UniversitäT Mainz
US Patent
Affinity DataIC50: 270nMAssay Description:Inhibition of human recombinant FLT3More data for this Ligand-Target Pair
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Eberhard-Karls University
Curated by ChEMBL
Eberhard-Karls University
Curated by ChEMBL
Affinity DataIC50: 3.50E+4nMAssay Description:Inhibition of human recombinant METMore data for this Ligand-Target Pair
TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
Eberhard-Karls University
Curated by ChEMBL
Eberhard-Karls University
Curated by ChEMBL
Affinity DataIC50: 680nMAssay Description:Inhibition of human recombinant PDGFRbetaMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase PLK4(Homo sapiens (Human))
Eberhard-Karls University
Curated by ChEMBL
Eberhard-Karls University
Curated by ChEMBL
Affinity DataIC50: 990nMAssay Description:Inhibition of human recombinant SAKMore data for this Ligand-Target Pair
Affinity DataIC50: 740nMAssay Description:Inhibition of human recombinant TIE2More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Johannes Gutenberg—Universitat Mainz
US Patent
Johannes Gutenberg—Universitat Mainz
US Patent
Affinity DataIC50: 26nMAssay Description:Inhibition of VEGFR2 after 80 mins by radiometric protein kinase assayMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 1(Homo sapiens (Human))
Hadassah Hebrew University Hospital
Curated by ChEMBL
Hadassah Hebrew University Hospital
Curated by ChEMBL
Affinity DataIC50: 55nMAssay Description:Inhibition of VEGFR1 after 80 mins by radiometric protein kinase assayMore data for this Ligand-Target Pair
Affinity DataIC50: 2.63E+3nMAssay Description:Inhibition of TIE2 after 80 mins by radiometric protein kinase assayMore data for this Ligand-Target Pair