BDBM484196 CDD-1713::WO2023004291, Compound CDD-1713

SMILES COc1cc(cc(C=O)c1OCC(=O)N(C)C)-c1cccc2[nH]ncc12

InChI Key InChIKey=LDHIKLLVVUEYPE-UHFFFAOYSA-N

Data  3 KI  1 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 484196   

TargetReplicase polyprotein 1ab-His6(2019-nCoV)
Baylor College Of Medicine

WIPO
LigandPNGBDBM484196(CDD-1713 | WO2023004291, Compound CDD-1713)
Affinity DataKi:  45nMAssay Description:To evaluate the potency of synthesized compounds against Mpro, the proteolytic activity of 50 nM Mpro -His and Mpro was first measured in the presenc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Baylor College Of Medicine

LigandPNGBDBM484196(CDD-1713 | WO2023004291, Compound CDD-1713)
Affinity DataKi:  65nMAssay Description:To determine the Ki values of active compounds, 25 nM Mpro was mixed with increasing concentrations of compounds (from 4 nM to 4,000 nM with twofold ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetReplicase polyprotein 1ab(2019-nCoV)
Baylor College Of Medicine

LigandPNGBDBM484196(CDD-1713 | WO2023004291, Compound CDD-1713)
Affinity DataKi:  65nMAssay Description:To evaluate the potency of synthesized compounds against Mpro, the proteolytic activity of 50 nM Mpro -His and Mpro was first measured in the presenc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetReplicase polyprotein 1ab(2019-nCoV)
Baylor College Of Medicine

LigandPNGBDBM484196(CDD-1713 | WO2023004291, Compound CDD-1713)
Affinity DataIC50:  5.19E+3nMAssay Description:Inhibition of SARS-CoV-2 replication in VERO E6 and HEK hACE2 cells was measured using an xCELLigence RTCA HT Analyzer (Agilent Technologies), tracki...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB