BDBM485660 US10940139, Example 02704::US11000515, Compound TABLE 7.255::US11213515, TABLE 7.255::US11541041, Compound Table 7.234

SMILES Oc1nc(nc2sccc12)-c1ccccn1

InChI Key InChIKey=CBIDWCOAELWUSK-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 485660   

TargetGTPase KRas [G12D](Homo sapiens (Human))
Shy Therapeutics

US Patent
LigandPNGBDBM485660(US10940139, Example 02704 | US11000515, Compound T...)
Affinity DataIC50:  2.05E+4nMAssay Description:Buffer-I: 50 mM Tris, pH 7.5 150 mM NaCl (optional) 1 mM MgCl2 1 mM DTT. KRas G12D mutant protein was expressed as...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGTPase KRas [G12D,Q61H](Homo sapiens (Human))
Shy Therapeutics

US Patent
LigandPNGBDBM485660(US10940139, Example 02704 | US11000515, Compound T...)
Affinity DataIC50:  2.05E+4nMAssay Description:The following method was developed as specific assay for KRas G12D mutant protein.Buffer-I:50 mM Tris, pH 7.5150 mM NaCl (optional)1 mM MgCl21 mM DTT...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGTPase KRas [G12D,Q61H](Homo sapiens (Human))
Shy Therapeutics

US Patent
LigandPNGBDBM485660(US10940139, Example 02704 | US11000515, Compound T...)
Affinity DataIC50:  2.05E+4nMAssay Description:The following method was developed as specific assay for KRas G12D mutant protein.Buffer-I: 50 mM Tris, pH 7.5 150 mM NaCl (optional) ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGTPase KRas [G12D,Q61H](Homo sapiens (Human))
Shy Therapeutics

US Patent
LigandPNGBDBM485660(US10940139, Example 02704 | US11000515, Compound T...)
Affinity DataIC50:  2.05E+4nMAssay Description:Buffer-I: 50 mM Tris, pH 7.5 150 mM NaCl (optional) 1 mM MgCl2 1 mM DTT. KRas G12D mutant protein was expressed as...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent